Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Fluorouracil
Drug ID BADD_D00931
Description A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the thymidylate synthetase conversion of deoxyuridylic acid to thymidylic acid.
Indications and Usage For the topical treatment of multiple actinic or solar keratoses. In the 5% strength it is also useful in the treatment of superficial basal cell carcinomas when conventional methods are impractical, such as with multiple lesions or difficult treatment sites. Fluorouracil injection is indicated in the palliative management of some types of cancer, including colon, esophageal, gastric, rectum, breast, biliary tract, stomach, head and neck, cervical, pancreas, renal cell, and carcinoid.
Marketing Status Prescription; Discontinued
ATC Code L01BC02
DrugBank ID DB00544
KEGG ID D00584
MeSH ID D005472
PubChem ID 3385
TTD Drug ID D05LEO
NDC Product Code 63323-117; 0378-8078; 51672-4062; 16714-178; 70700-189; 51862-362; 51672-4118; 70700-186; 50090-4264; 38779-0025; 51672-4063; 0378-4791; 68001-524; 25021-215; 68001-266; 62049-185; 38779-3185; 16729-276; 68001-525; 0187-3204; 68083-269; 68083-293; 51927-1085; 68083-270; 66530-249; 28105-421; 16110-812; 68083-292; 70700-187; 0187-5200; 70700-188; 59348-0055; 12070-0002; 49452-3175; 16729-542; 0395-8080; 62991-1486
Synonyms Fluorouracil | 5FU | 5-FU | 5-Fluorouracil | 5 Fluorouracil | Fluoruracil | 5-FU Lederle | 5 FU Lederle | 5-FU Medac | 5 FU Medac | 5-HU Hexal | 5 HU Hexal | Adrucil | Carac | Efudix | Fluoro-Uracile ICN | Fluoro Uracile ICN | Efudex | Fluoroplex | Flurodex | Fluorouracil Mononitrate | Fluorouracil Monopotassium Salt | Fluorouracil Monosodium Salt | Fluorouracil Potassium Salt | Fluorouracil-GRY | Fluorouracil GRY | Fluorouracile Dakota | Dakota, Fluorouracile | Fluorouracilo Ferrer Far | Fluracedyl | Haemato-FU | Haemato FU | Neofluor | Onkofluor | Ribofluor | 5-Fluorouracil-Biosyn | 5 Fluorouracil Biosyn
Chemical Information
Molecular Formula C4H3FN2O2
CAS Registry Number 51-21-8
SMILES C1=C(C(=O)NC(=O)N1)F
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
ApoptosisSoluble TNF receptor IIP68636Not Available14614330; 15546879; 10583368
Bone marrow toxicityDihydropyrimidine dehydrogenase [NADP(+)]Q12882T758909552051; 8955653; 10673535
Bone marrow toxicityDihydropyrimidine dehydrogenase [NADP(+)]Q12882T7589015228171; 9893619; 12525681
Bone marrow toxicityDihydropyrimidine dehydrogenase [NADP(+)]Q12882T758907882316; 8248211; 8137256
Drug effect decreasedDihydropyrimidine dehydrogenase [NADP(+)]Q12882T7589015228171; 9893619; 12525681
Drug effect decreasedDihydropyrimidine dehydrogenase [NADP(+)]Q12882T758907882316; 8248211; 8137256
Drug effect decreasedDihydropyrimidine dehydrogenase [NADP(+)]Q12882T758909552051; 8955653; 10673535
NeurotoxicityDihydropyrimidine dehydrogenase [NADP(+)]Q12882T758907882316; 8248211; 8137256
NeurotoxicityDihydropyrimidine dehydrogenase [NADP(+)]Q12882T758909552051; 8955653; 10673535
NeurotoxicityDihydropyrimidine dehydrogenase [NADP(+)]Q12882T7589015228171; 9893619; 12525681
Toxicity to various agentsDihydropyrimidine dehydrogenase [NADP(+)]Q12882T758909552051; 8955653; 10673535
Toxicity to various agentsDihydropyrimidine dehydrogenase [NADP(+)]Q12882T7589015228171; 9893619; 12525681
Toxicity to various agentsDihydropyrimidine dehydrogenase [NADP(+)]Q12882T758907882316; 8248211; 8137256
VomitingDihydropyrimidine dehydrogenase [NADP(+)]Q12882T758909552051; 8955653; 10673535
VomitingDihydropyrimidine dehydrogenase [NADP(+)]Q12882T7589015228171; 9893619; 12525681
VomitingDihydropyrimidine dehydrogenase [NADP(+)]Q12882T758907882316; 8248211; 8137256
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Intracranial pressure increased17.07.02.0020.000941%Not Available
Irritability08.01.03.011; 19.04.02.013--
Jaundice23.03.03.030; 09.01.01.004; 01.06.04.004--Not Available
Joint swelling15.01.02.004--Not Available
Keratoacanthoma23.08.02.007; 16.03.02.0070.001411%Not Available
Keratopathy06.06.03.0070.000941%Not Available
Lacrimation increased06.08.02.0040.001411%
Lactic acidosis14.01.01.002--Not Available
Laryngeal oedema23.04.01.005; 22.04.02.001; 10.01.05.0030.000941%
Laryngeal pain22.02.05.0360.002352%
Laryngospasm22.04.02.0020.002352%
Lethargy19.04.04.004; 17.02.04.003; 08.01.01.0080.003763%
Leukocytosis01.02.01.0020.000941%
Leukoencephalopathy17.13.02.0030.010349%
Leukopenia01.02.02.0010.023991%Not Available
Lip swelling07.05.04.005; 23.04.01.007; 10.01.05.0050.001882%Not Available
Liver disorder09.01.08.001--Not Available
Local reaction08.01.03.012--Not Available
Loss of consciousness17.02.04.0040.005645%Not Available
Lower respiratory tract infection22.07.01.002; 11.01.09.0020.001411%Not Available
Lung disorder22.02.07.0010.002823%Not Available
Lymphadenopathy01.09.01.0020.002352%Not Available
Lymphopenia01.02.02.0020.000941%Not Available
Malaise08.01.01.003--
Melaena24.07.02.013; 07.12.02.004--Not Available
Metabolic acidosis14.01.01.003--Not Available
Metastases to liver16.22.02.001; 09.04.02.0040.000982%Not Available
Metastases to lung16.22.02.002; 22.08.01.0050.000491%Not Available
Mouth ulceration07.05.06.0040.002352%Not Available
Mucosal inflammation08.01.06.0020.026814%Not Available
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