Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Ferumoxytol
Drug ID BADD_D00889
Description Ferumoxytol is an intravenously administered iron preparation indicated in the EU and the US for the treatment of iron deficiency anemia in adult patients with chronic kidney disease (CKD) [A32478]. It is comprised of superparamagnetic iron oxide nanoparticles which are coated by a semi-synthetic carbohydrate shell in an isotonic, neutral pH solution that may be administered at relatively high dose by rapid intravenous injection [L2181].
Indications and Usage Investigated for use/treatment in anemia, kidney disease, and cardiovascular disorders.
Marketing Status Prescription
ATC Code Not Available
DrugBank ID DB06215
KEGG ID D04177
MeSH ID D052203
PubChem ID 14789
TTD Drug ID D06CTM
NDC Product Code 0781-3154; 59338-775
Synonyms Ferrosoferric Oxide | Oxide, Ferrosoferric | Ferriferrous Oxide | Oxide, Ferriferrous | Magnetite | Feraheme | Ferumoxytol
Chemical Information
Molecular Formula Fe3H2O4
CAS Registry Number 1317-61-9
SMILES O[Fe]=O.O[Fe]=O.[Fe]
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain07.01.05.002--
Anaphylactic reaction24.06.03.006; 10.01.07.001--
Angioedema23.04.01.001; 10.01.05.009--Not Available
Back pain15.03.04.005--
Cardio-respiratory arrest02.03.04.002; 22.02.06.007--Not Available
Chest pain22.02.08.003; 08.01.08.002; 02.02.02.011--Not Available
Cough22.02.03.001--
Cyanosis24.03.01.007; 22.02.02.007; 02.01.02.002--
Dizziness24.06.02.007; 17.02.05.003; 02.01.02.004--
Dyspnoea22.02.01.004; 02.01.03.002--
Headache17.14.01.001--
Hypotension24.06.03.002--
Loss of consciousness17.02.04.004--Not Available
Muscle spasms15.05.03.004--
Nausea07.01.07.001--
Oedema14.05.06.010; 08.01.07.006--Not Available
Oedema peripheral14.05.06.011; 08.01.07.007; 02.05.04.007--
Pruritus23.03.12.001--
Pulse absent13.14.04.005--Not Available
Pyrexia08.05.02.003--
Rash23.03.13.001--Not Available
Syncope24.06.02.012; 17.02.04.008; 02.01.02.008--
Tachycardia02.03.02.007--Not Available
Unresponsive to stimuli17.02.05.031--Not Available
Vomiting07.01.07.003--
Ischaemic cardiomyopathy24.04.04.019; 02.04.01.004--Not Available
Congestive cardiomyopathy02.04.01.003--Not Available
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