Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Fentanyl
Drug ID BADD_D00879
Description Fentanyl, a potent opioid agonist, was developed in the 1950s to fill a need for strong and rapid analgesia.[A179542] Because of these characteristics, fentanyl is commonly used to treat chronic cancer pain or in anesthesia.[Label,L6598,L6601,L6604,L6607,L922,L6610,L6613] Fentanyl is related to other opioids like [morphine] and [oxycodone]. Fentanyl's high potency has also made it a common adulterant in illicit drugs, especially heroin.[A179542] In 2017, 47600 overdose deaths in the United States involved some opioid (over 2/3 of all overdose deaths).[L6748] Opioid overdoses kill an average of 11 Canadians daily.[L6751] Fentanyl was FDA approved in 1968.[Label,L6598,L6601,L6604,L6607,L922,L6610,L6613]
Indications and Usage For the treatment of cancer patients with severe pain that breaks through their regular narcotic therapy.
Marketing Status Prescription; Discontinued
ATC Code N01AH01; N02AB03
DrugBank ID DB00813
KEGG ID D00320
MeSH ID D005283
PubChem ID 3345
TTD Drug ID D0E1WI
NDC Product Code 0378-9123; 63459-542; 63629-4976; 0378-9122; 20482-006; 59116-2640; 0378-9125; 60505-7016; 0378-9124; 0378-9121; 63629-4974; 60505-7010; 60505-7009; 71500-002; 55700-749; 50458-105; 59116-2641; 59116-2646; 71335-1260; 71500-140; 71500-001; 71335-0376; 60505-7015; 71500-016; 60505-7082; 50458-106; 59116-2645; 61919-602; 59116-2644; 60505-7006; 60505-7013; 60505-7012; 20482-012; 20482-016; 64181-0008; 50458-101; 55700-748; 59116-2643; 47781-426; 71500-110; 50458-104; 63459-544; 63459-541; 60505-7084; 63459-548; 59116-2642; 20482-004; 47781-423; 55700-753; 71335-1227; 71500-130; 47781-428; 71335-1228; 60505-7081; 60505-7080; 47781-424; 50458-102; 0378-9119; 60505-7007; 0378-9127; 20482-001; 61919-603; 71500-008; 63459-546; 71500-012; 71335-1404; 47781-427; 60505-7014; 71335-1224; 71335-1403; 60505-7085; 20482-002; 71500-006; 71500-004; 63629-4813; 20482-008; 60505-7008; 60505-7087; 55700-811; 0378-9126; 60505-7086; 60505-7083; 60505-7011; 60505-7017
Synonyms Fentanyl | Phentanyl | Fentanest | Fentanyl Citrate | R-4263 | R 4263 | R4263 | Sublimaze | Transmucosal Oral Fentanyl Citrate | Duragesic | Durogesic | Fentora
Chemical Information
Molecular Formula C22H28N2O
CAS Registry Number 437-38-7
SMILES CCC(=O)N(C1CCN(CC1)CCC2=CC=CC=C2)C3=CC=CC=C3
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Drug tolerance increasedAdenylate cyclase type 1Q08828T636099618424; 8995364; 9271350; 10945855; 9862403; 15383633; 12726892
Drug tolerance increasedMu-type opioid receptorP35372T477689618424; 8995364; 9271350; 10945855; 9862403; 15383633; 12726892; 15475572
PainOpioid growth factor receptorQ9NZT2T1374114680764; 14662727; 10691234; 11438608
PainAbscisic acid-inducible protein kinaseQ02066Not Available14680764; 14662727; 10691234; 11438608
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Hypothermia12.05.03.001; 08.05.01.003--
Hypotonia17.05.02.002; 15.05.04.0080.001452%Not Available
Hypoventilation22.02.01.007--Not Available
Hypoxia22.02.02.003--
Ileus07.13.01.001--
Immune system disorder10.02.01.001--Not Available
Impaired gastric emptying07.02.02.004--
Impaired healing08.03.02.001--Not Available
Incoherent19.10.03.006; 17.02.08.0020.000968%Not Available
Increased appetite14.03.01.003; 08.01.09.027--Not Available
Infection11.01.08.002--Not Available
Influenza22.07.02.001; 11.05.03.001--Not Available
Influenza like illness08.01.03.010--
Injection site pain12.07.03.011; 08.02.03.010--Not Available
Injury12.01.08.004--Not Available
Insomnia17.15.03.002; 19.02.01.002--
Instillation site pain08.02.01.008; 12.07.01.008--Not Available
Interstitial lung disease22.01.02.003; 10.02.01.033--Not Available
Intestinal obstruction07.13.01.0020.002420%Not Available
Intestinal perforation07.04.06.0020.000968%Not Available
Intracranial pressure increased17.07.02.002--Not Available
Irritability19.04.02.013; 08.01.03.011--
Jaundice09.01.01.004; 01.06.04.004; 23.03.03.030--Not Available
Joint swelling15.01.02.004--Not Available
Laceration23.03.11.004; 12.01.06.0060.000968%Not Available
Laryngeal pain22.02.05.036--
Laryngitis22.07.03.001; 11.01.13.001--
Laryngospasm22.04.02.002--
Lethargy17.02.04.003; 08.01.01.008; 19.04.04.004--
Leukocytosis01.02.01.0020.002420%
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