Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Fentanyl
Drug ID BADD_D00879
Description Fentanyl, a potent opioid agonist, was developed in the 1950s to fill a need for strong and rapid analgesia.[A179542] Because of these characteristics, fentanyl is commonly used to treat chronic cancer pain or in anesthesia.[Label,L6598,L6601,L6604,L6607,L922,L6610,L6613] Fentanyl is related to other opioids like [morphine] and [oxycodone]. Fentanyl's high potency has also made it a common adulterant in illicit drugs, especially heroin.[A179542] In 2017, 47600 overdose deaths in the United States involved some opioid (over 2/3 of all overdose deaths).[L6748] Opioid overdoses kill an average of 11 Canadians daily.[L6751] Fentanyl was FDA approved in 1968.[Label,L6598,L6601,L6604,L6607,L922,L6610,L6613]
Indications and Usage For the treatment of cancer patients with severe pain that breaks through their regular narcotic therapy.
Marketing Status Prescription; Discontinued
ATC Code N01AH01; N02AB03
DrugBank ID DB00813
KEGG ID D00320
MeSH ID D005283
PubChem ID 3345
TTD Drug ID D0E1WI
NDC Product Code 0378-9123; 63459-542; 63629-4976; 0378-9122; 20482-006; 59116-2640; 0378-9125; 60505-7016; 0378-9124; 0378-9121; 63629-4974; 60505-7010; 60505-7009; 71500-002; 55700-749; 50458-105; 59116-2641; 59116-2646; 71335-1260; 71500-140; 71500-001; 71335-0376; 60505-7015; 71500-016; 60505-7082; 50458-106; 59116-2645; 61919-602; 59116-2644; 60505-7006; 60505-7013; 60505-7012; 20482-012; 20482-016; 64181-0008; 50458-101; 55700-748; 59116-2643; 47781-426; 71500-110; 50458-104; 63459-544; 63459-541; 60505-7084; 63459-548; 59116-2642; 20482-004; 47781-423; 55700-753; 71335-1227; 71500-130; 47781-428; 71335-1228; 60505-7081; 60505-7080; 47781-424; 50458-102; 0378-9119; 60505-7007; 0378-9127; 20482-001; 61919-603; 71500-008; 63459-546; 71500-012; 71335-1404; 47781-427; 60505-7014; 71335-1224; 71335-1403; 60505-7085; 20482-002; 71500-006; 71500-004; 63629-4813; 20482-008; 60505-7008; 60505-7087; 55700-811; 0378-9126; 60505-7086; 60505-7083; 60505-7011; 60505-7017
Synonyms Fentanyl | Phentanyl | Fentanest | Fentanyl Citrate | R-4263 | R 4263 | R4263 | Sublimaze | Transmucosal Oral Fentanyl Citrate | Duragesic | Durogesic | Fentora
Chemical Information
Molecular Formula C22H28N2O
CAS Registry Number 437-38-7
SMILES CCC(=O)N(C1CCN(CC1)CCC2=CC=CC=C2)C3=CC=CC=C3
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Drug tolerance increasedAdenylate cyclase type 1Q08828T636099618424; 8995364; 9271350; 10945855; 9862403; 15383633; 12726892
Drug tolerance increasedMu-type opioid receptorP35372T477689618424; 8995364; 9271350; 10945855; 9862403; 15383633; 12726892; 15475572
PainOpioid growth factor receptorQ9NZT2T1374114680764; 14662727; 10691234; 11438608
PainAbscisic acid-inducible protein kinaseQ02066Not Available14680764; 14662727; 10691234; 11438608
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Lacrimal structural disorder06.06.04.013--Not Available
Candida infection11.03.03.021--
Intentional product misuse12.08.02.002--Not Available
Sinus node dysfunction02.03.03.0170.000968%
Multiple organ dysfunction syndrome08.01.03.057--
Anal incontinence17.05.01.021; 07.01.06.029--
Depersonalisation/derealisation disorder19.14.01.004--Not Available
Alcohol interaction08.06.03.0030.001452%Not Available
Anion gap13.02.01.0180.000757%Not Available
Brain neoplasm malignant17.20.04.002; 16.30.04.0020.000252%Not Available
Endometrial cancer metastatic21.07.02.012; 16.12.02.0040.000252%Not Available
Lung carcinoma cell type unspecified stage IV22.08.01.019; 16.19.02.0060.000252%Not Available
Metastases to bone16.22.02.005; 15.09.03.0060.000379%Not Available
Pancreatic carcinoma metastatic16.13.10.003; 07.21.09.0060.000884%Not Available
Terminal state08.01.03.0790.000252%Not Available
Breast cancer metastatic21.05.01.016; 16.10.01.0080.001389%Not Available
Colon cancer metastatic16.13.01.012; 07.21.01.0100.000631%Not Available
Ovarian cancer metastatic21.11.01.013; 16.12.04.0040.000379%Not Available
Mitochondrial encephalomyopathy17.13.02.009; 15.05.05.014; 03.18.01.0060.000968%Not Available
Small cell lung cancer metastatic16.19.08.002; 22.08.01.0120.000252%Not Available
Heart injury12.01.11.003; 02.01.01.0100.001010%Not Available
Toxicologic test abnormal13.17.02.0140.000379%Not Available
Acute lung injury22.01.03.0100.000505%Not Available
Coma scale abnormal13.07.03.0120.006291%Not Available
Poor feeding infant18.04.06.006; 14.03.02.0220.000968%Not Available
Toxic leukoencephalopathy12.03.01.059; 17.13.02.0120.003871%Not Available
Unmasking of previously unidentified disease08.01.03.0800.000968%Not Available
Tongue discomfort07.14.02.0190.000968%Not Available
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