Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Fentanyl
Drug ID BADD_D00879
Description Fentanyl, a potent opioid agonist, was developed in the 1950s to fill a need for strong and rapid analgesia.[A179542] Because of these characteristics, fentanyl is commonly used to treat chronic cancer pain or in anesthesia.[Label,L6598,L6601,L6604,L6607,L922,L6610,L6613] Fentanyl is related to other opioids like [morphine] and [oxycodone]. Fentanyl's high potency has also made it a common adulterant in illicit drugs, especially heroin.[A179542] In 2017, 47600 overdose deaths in the United States involved some opioid (over 2/3 of all overdose deaths).[L6748] Opioid overdoses kill an average of 11 Canadians daily.[L6751] Fentanyl was FDA approved in 1968.[Label,L6598,L6601,L6604,L6607,L922,L6610,L6613]
Indications and Usage For the treatment of cancer patients with severe pain that breaks through their regular narcotic therapy.
Marketing Status Prescription; Discontinued
ATC Code N01AH01; N02AB03
DrugBank ID DB00813
KEGG ID D00320
MeSH ID D005283
PubChem ID 3345
TTD Drug ID D0E1WI
NDC Product Code 0378-9123; 63459-542; 63629-4976; 0378-9122; 20482-006; 59116-2640; 0378-9125; 60505-7016; 0378-9124; 0378-9121; 63629-4974; 60505-7010; 60505-7009; 71500-002; 55700-749; 50458-105; 59116-2641; 59116-2646; 71335-1260; 71500-140; 71500-001; 71335-0376; 60505-7015; 71500-016; 60505-7082; 50458-106; 59116-2645; 61919-602; 59116-2644; 60505-7006; 60505-7013; 60505-7012; 20482-012; 20482-016; 64181-0008; 50458-101; 55700-748; 59116-2643; 47781-426; 71500-110; 50458-104; 63459-544; 63459-541; 60505-7084; 63459-548; 59116-2642; 20482-004; 47781-423; 55700-753; 71335-1227; 71500-130; 47781-428; 71335-1228; 60505-7081; 60505-7080; 47781-424; 50458-102; 0378-9119; 60505-7007; 0378-9127; 20482-001; 61919-603; 71500-008; 63459-546; 71500-012; 71335-1404; 47781-427; 60505-7014; 71335-1224; 71335-1403; 60505-7085; 20482-002; 71500-006; 71500-004; 63629-4813; 20482-008; 60505-7008; 60505-7087; 55700-811; 0378-9126; 60505-7086; 60505-7083; 60505-7011; 60505-7017
Synonyms Fentanyl | Phentanyl | Fentanest | Fentanyl Citrate | R-4263 | R 4263 | R4263 | Sublimaze | Transmucosal Oral Fentanyl Citrate | Duragesic | Durogesic | Fentora
Chemical Information
Molecular Formula C22H28N2O
CAS Registry Number 437-38-7
SMILES CCC(=O)N(C1CCN(CC1)CCC2=CC=CC=C2)C3=CC=CC=C3
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Drug tolerance increasedAdenylate cyclase type 1Q08828T636099618424; 8995364; 9271350; 10945855; 9862403; 15383633; 12726892
Drug tolerance increasedMu-type opioid receptorP35372T477689618424; 8995364; 9271350; 10945855; 9862403; 15383633; 12726892; 15475572
PainOpioid growth factor receptorQ9NZT2T1374114680764; 14662727; 10691234; 11438608
PainAbscisic acid-inducible protein kinaseQ02066Not Available14680764; 14662727; 10691234; 11438608
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Anosmia22.04.03.006; 17.04.04.001--
Anterograde amnesia19.20.01.005; 17.03.02.0050.001452%Not Available
Anuria20.01.03.002--Not Available
Anxiety19.06.02.002--
Aphasia19.21.01.001; 17.02.03.001--
Aphthous ulcer07.05.06.0020.001452%Not Available
Apnoea22.02.01.0010.008710%
Application site dermatitis23.03.04.014; 12.07.01.018; 08.02.01.018--Not Available
Application site erythema08.02.01.001; 23.03.06.005; 12.07.01.001--Not Available
Application site irritation12.07.01.003; 08.02.01.003--Not Available
Application site pain12.07.01.004; 08.02.01.004--Not Available
Application site rash12.07.01.016; 08.02.01.016; 23.03.13.008--Not Available
Application site reaction12.07.01.006; 08.02.01.006--Not Available
Application site ulcer23.07.03.010; 12.07.01.007; 08.02.01.007--Not Available
Arrhythmia02.03.02.001--Not Available
Arteriosclerosis24.04.02.0010.000252%Not Available
Arthralgia15.01.02.001--
Arthritis15.01.01.001--
Arthropathy15.01.01.003--Not Available
Ascites09.01.05.003; 07.07.01.001; 02.05.04.002--
Aspartate aminotransferase increased13.03.01.006--
Aspiration22.02.07.0070.000379%
Asthenia08.01.01.001--Not Available
Asthma22.03.01.002; 10.01.03.010--Not Available
Atelectasis22.01.02.001--
Atrial fibrillation02.03.03.002--
Attention deficit/hyperactivity disorder19.21.04.001--Not Available
Autonomic nervous system imbalance17.05.01.011; 08.01.01.010; 24.06.01.0050.000968%Not Available
Back pain15.03.04.005--
Bladder pain20.02.02.001--Not Available
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