Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Felodipine
Drug ID BADD_D00872
Description Felodipine is a long-acting 1,4-dihydropyridine calcium channel blocker (CCB)b. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. By inhibiting the influx of calcium in smooth muscle cells, felodipine prevents calcium-dependent myocyte contraction and vasoconstriction. Felodipine is the most potent CCB in use and is unique in that it exhibits fluorescent activity. In addition to binding to L-type calcium channels, felodipine binds to a number of calcium-binding proteins, exhibits competitive antagonism of the mineralcorticoid receptor, inhibits the activity of calmodulin-dependent cyclic nucleotide phosphodiesterase, and blocks calcium influx through voltage-gated T-type calcium channels. Felodipine is used to treat mild to moderate essential hypertension.
Indications and Usage For the treatment of mild to moderate essential hypertension.
Marketing Status Prescription; Discontinued
ATC Code C08CA02
DrugBank ID DB01023
KEGG ID D00319
MeSH ID D015736
PubChem ID 3333
TTD Drug ID D0WN0U
NDC Product Code 53489-369; 63629-2017; 63629-2194; 71205-922; 53296-0041; 23155-048; 51407-088; 65862-674; 50090-5870; 13668-132; 63629-2193; 63629-2191; 66406-0275; 23155-050; 65862-673; 61442-432; 61442-431; 63629-2018; 71335-1486; 50090-2421; 64679-412; 71335-1318; 65862-399; 51407-087; 57237-109; 63629-2192; 66406-0276; 65035-105; 53104-7519; 0603-3582; 0603-3583; 13668-133; 14799-2007; 63629-2016; 53489-368; 23155-049; 57237-110; 63629-2196; 64679-414; 58657-685; 66406-0277; 61442-433; 13668-134; 57237-108; 65862-675; 46708-926; 68462-233; 63629-2195; 58657-687; 51407-089; 68462-235; 53489-370; 68462-234; 71205-921; 71205-920; 58657-686; 64679-411; 0603-3581
Synonyms Felodipine | Felo Biochemie | Felo-Puren | Felo Puren | Felobeta | Felocor | Felodipin 1A Pharma | Felodipin AbZ | Felodipin AL | Felodipin AZU | Felodipin Dura | Felodipin Heumann | Heumann, Felodipin | Felodipin Stada | Felodipin Von Ct | Von Ct, Felodipin | Felodipin-Ratiopharm | Felodipin Ratiopharm | Felodur | Felogamma | Fensel | H 154-82 | H 154 82 | H 15482 | Perfudal | Plendil | Flodil | Modip | Renedil | Munobal | Agon
Chemical Information
Molecular Formula C18H19Cl2NO4
CAS Registry Number 72509-76-3
SMILES CCOC(=O)C1=C(NC(=C(C1C2=C(C(=CC=C2)Cl)Cl)C(=O)OC)C)C
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.001--Not Available
Abdominal pain07.01.05.002--
Acne23.02.01.0010.001599%Not Available
Alanine aminotransferase increased13.03.01.003--
Alopecia23.02.02.0010.003997%
Anaemia01.03.02.001--
Anaphylactoid reaction24.06.03.007; 10.01.07.0030.005596%Not Available
Angina pectoris24.04.04.002; 02.02.02.002--
Angioedema10.01.05.009; 23.04.01.0010.002398%Not Available
Anxiety19.06.02.0020.003997%
Arrhythmia02.03.02.001--Not Available
Arthralgia15.01.02.001--
Asthenia08.01.01.001--Not Available
Atrioventricular block second degree02.03.01.005--
Back pain15.03.04.005--
Blister23.03.01.001; 12.01.06.0020.001599%Not Available
Body temperature increased13.15.01.001--Not Available
Bradycardia02.03.02.002--Not Available
Bronchitis22.07.01.001; 11.01.09.001--
Cerebrovascular accident24.03.05.001; 17.08.01.007--
Chest pain22.02.08.003; 08.01.08.002; 02.02.02.0110.002398%Not Available
Coma17.02.09.0010.001599%Not Available
Confusional state17.02.03.005; 19.13.01.001--
Constipation07.02.02.001--
Cough22.02.03.001--
Depression19.15.01.001--
Dermatitis23.03.04.002--Not Available
Diarrhoea07.02.01.001--
Dizziness24.06.02.007; 02.01.02.004; 17.02.05.0030.006396%
Dry mouth07.06.01.002--
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