Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Etonogestrel
Drug ID BADD_D00852
Description Etonogestrel molecule is a 3-ketodesogestrel or 19-nortestosterone which is a synthetic biologically active metabolite of progestin desogestrel.[A37184] The first product including etonogestrel was developed by the Merck subsidiary Organon and FDA approved in 2001.[L5692]
Indications and Usage For use as a female contraceptive (depot).
Marketing Status Prescription; Discontinued
ATC Code G03AC08
DrugBank ID DB00294
KEGG ID D04104
MeSH ID C044815
PubChem ID 6917715
TTD Drug ID D02KIU
NDC Product Code 65089-0053; 64918-1500; 60870-0475; 78206-145; 71161-147; 63190-0480; 63190-0260; 45541-1192; 64918-1906
Synonyms etonogestrel | 13-ethyl-17-hydroxy-11-methylene-18,19-dinor-17alpha-pregn-4-en-20-yn-3-one | 3-oxodesogestrel | 3-ketodesogestrel | 3-oxo desogestrel | 18,19-dinorpregn-4-en-20-yn-3-one, 13-ethyl-17-hydroxy-11-methylene-, (17-alpha)- | 3-keto-desogestrel | ORG-3236 | Implanon | nexplanon
Chemical Information
Molecular Formula C22H28O2
CAS Registry Number 54048-10-1
SMILES CCC12CC(=C)C3C(C1CCC2(C#C)O)CCC4=CC(=O)CCC34
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Nervous system disorder17.02.10.001--Not Available
Nervousness19.06.02.0030.009486%Not Available
Neuralgia17.02.07.0050.014023%
Neuropathy peripheral17.09.03.003--Not Available
Night sweats08.01.03.031; 23.02.03.0060.002887%Not Available
Nightmare19.02.03.003--Not Available
Nipple disorder21.05.04.0060.001237%
Nipple pain21.05.05.0090.002887%Not Available
Nuclear magnetic resonance imaging13.18.03.0010.004949%Not Available
Obesity14.03.02.0090.008249%
Obsessive-compulsive disorder19.06.05.002--Not Available
Ocular hyperaemia06.04.05.004--Not Available
Oedema14.05.06.010; 08.01.07.006--Not Available
Oedema peripheral08.01.07.007; 14.05.06.011; 02.05.04.007--
Oligomenorrhoea21.01.02.004; 05.05.01.0110.023922%Not Available
Oral mucosal blistering07.05.05.0170.000825%Not Available
Otitis media04.05.01.001; 11.01.05.004--
Ovarian cyst21.11.01.002; 16.04.03.0010.010724%Not Available
Pain08.01.08.0040.095276%
Pain in extremity15.03.04.0100.179416%
Pain of skin23.03.03.0030.002475%
Pallor23.03.03.031; 08.01.03.032; 24.03.04.0010.002887%Not Available
Palpitations02.01.02.003--
Panic attack19.06.04.001--Not Available
Papilloedema24.03.07.001; 17.07.02.004; 06.09.02.0020.001650%
Paraesthesia17.02.06.0050.069292%
Paralysis17.01.04.004--Not Available
Paranoia19.05.01.005--Not Available
Parosmia22.04.03.007; 17.04.04.0020.001237%Not Available
Pelvic pain21.10.01.001; 20.02.03.007; 07.01.06.0120.009899%
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