Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Etonogestrel
Drug ID BADD_D00852
Description Etonogestrel molecule is a 3-ketodesogestrel or 19-nortestosterone which is a synthetic biologically active metabolite of progestin desogestrel.[A37184] The first product including etonogestrel was developed by the Merck subsidiary Organon and FDA approved in 2001.[L5692]
Indications and Usage For use as a female contraceptive (depot).
Marketing Status Prescription; Discontinued
ATC Code G03AC08
DrugBank ID DB00294
KEGG ID D04104
MeSH ID C044815
PubChem ID 6917715
TTD Drug ID D02KIU
NDC Product Code 65089-0053; 64918-1500; 60870-0475; 78206-145; 71161-147; 63190-0480; 63190-0260; 45541-1192; 64918-1906
Synonyms etonogestrel | 13-ethyl-17-hydroxy-11-methylene-18,19-dinor-17alpha-pregn-4-en-20-yn-3-one | 3-oxodesogestrel | 3-ketodesogestrel | 3-oxo desogestrel | 18,19-dinorpregn-4-en-20-yn-3-one, 13-ethyl-17-hydroxy-11-methylene-, (17-alpha)- | 3-keto-desogestrel | ORG-3236 | Implanon | nexplanon
Chemical Information
Molecular Formula C22H28O2
CAS Registry Number 54048-10-1
SMILES CCC12CC(=C)C3C(C1CCC2(C#C)O)CCC4=CC(=O)CCC34
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Mastitis21.05.03.002; 11.01.02.0010.000825%
Memory impairment19.20.01.003; 17.03.02.003--
Meningioma17.20.01.005; 16.30.01.0050.000825%Not Available
Menometrorrhagia21.01.03.0010.041658%Not Available
Menopausal symptoms21.02.02.002--Not Available
Menorrhagia21.01.03.0020.375742%
Menstrual disorder21.01.01.0040.070529%Not Available
Menstruation delayed21.01.02.003; 05.05.01.0100.051556%Not Available
Menstruation irregular21.01.01.005; 05.05.01.0080.277167%
Metrorrhagia21.01.01.0060.209937%Not Available
Middle insomnia19.02.01.003; 17.15.03.0030.001650%Not Available
Migraine24.03.05.003; 17.14.02.0010.044545%Not Available
Migraine with aura17.14.02.002; 24.03.05.0050.002062%Not Available
Monoplegia17.01.04.0030.000825%Not Available
Mood altered19.04.02.0070.042895%Not Available
Mood swings19.04.03.0010.086615%Not Available
Movement disorder17.01.02.0100.008249%Not Available
Multiple sclerosis17.16.01.001; 10.04.10.008--Not Available
Muscle spasms15.05.03.0040.054443%
Muscle twitching15.05.03.005--Not Available
Muscular weakness17.05.03.005; 15.05.06.001--
Musculoskeletal pain15.03.04.0070.009899%
Myalgia15.05.02.001--
Myocardial infarction24.04.04.009; 02.02.02.007--
Nasopharyngitis22.07.03.002; 11.01.13.002--Not Available
Nausea07.01.07.0010.120848%
Neck pain15.03.04.0090.009074%
Neoplasm16.16.02.001--Not Available
Nephrolithiasis20.04.01.002--
Nerve compression17.09.02.002; 12.01.12.0010.004537%Not Available
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