Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Etonogestrel
Drug ID BADD_D00852
Description Etonogestrel molecule is a 3-ketodesogestrel or 19-nortestosterone which is a synthetic biologically active metabolite of progestin desogestrel.[A37184] The first product including etonogestrel was developed by the Merck subsidiary Organon and FDA approved in 2001.[L5692]
Indications and Usage For use as a female contraceptive (depot).
Marketing Status Prescription; Discontinued
ATC Code G03AC08
DrugBank ID DB00294
KEGG ID D04104
MeSH ID C044815
PubChem ID 6917715
TTD Drug ID D02KIU
NDC Product Code 65089-0053; 64918-1500; 60870-0475; 78206-145; 71161-147; 63190-0480; 63190-0260; 45541-1192; 64918-1906
Synonyms etonogestrel | 13-ethyl-17-hydroxy-11-methylene-18,19-dinor-17alpha-pregn-4-en-20-yn-3-one | 3-oxodesogestrel | 3-ketodesogestrel | 3-oxo desogestrel | 18,19-dinorpregn-4-en-20-yn-3-one, 13-ethyl-17-hydroxy-11-methylene-, (17-alpha)- | 3-keto-desogestrel | ORG-3236 | Implanon | nexplanon
Chemical Information
Molecular Formula C22H28O2
CAS Registry Number 54048-10-1
SMILES CCC12CC(=C)C3C(C1CCC2(C#C)O)CCC4=CC(=O)CCC34
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Candida infection11.03.03.021--
Perforation08.01.03.0580.000825%Not Available
Frustration tolerance decreased19.04.02.0160.000825%Not Available
Bacterial vaginosis21.14.02.012; 11.02.01.0260.002475%Not Available
Body mass index increased13.15.01.0380.002062%Not Available
Laboratory test interference13.18.01.0080.000825%Not Available
Ovarian cyst ruptured21.11.01.015; 16.04.03.0060.001237%Not Available
Overweight14.03.02.0210.003712%Not Available
Placenta praevia18.05.02.0040.000825%Not Available
Post-traumatic stress disorder19.06.06.0020.001237%Not Available
Purulent discharge11.01.08.061; 08.01.03.0760.002062%Not Available
Staphylococcal abscess11.02.05.0130.001237%Not Available
Ulnar nerve injury17.09.02.016; 12.01.01.0050.002887%Not Available
Vomiting in pregnancy18.02.02.017; 07.01.07.0150.004125%Not Available
Ruptured ectopic pregnancy18.02.02.0050.002475%Not Available
Upper extremity mass15.03.01.0160.000825%Not Available
Lower extremity mass15.03.01.0150.000825%Not Available
Axillary mass15.03.02.0140.000825%Not Available
Weight loss poor14.03.02.0270.002475%Not Available
Neck mass15.03.02.0070.000825%Not Available
Skin turgor decreased13.15.01.0230.001237%Not Available
Subclavian vein thrombosis24.01.02.0130.000825%Not Available
Haematoma infection24.07.01.068; 11.01.15.0040.000825%Not Available
Postpartum depression19.15.01.008; 18.06.03.0020.001650%Not Available
Uterine cervical pain21.06.01.0140.001237%Not Available
Ovarian mass21.11.02.0170.000825%Not Available
Purulence11.01.08.0600.002887%Not Available
Grip strength decreased13.15.01.0410.001237%Not Available
Progesterone decreased13.10.05.0280.001237%Not Available
Progesterone increased13.10.05.0290.000825%Not Available
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