Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Etonogestrel
Drug ID BADD_D00852
Description Etonogestrel molecule is a 3-ketodesogestrel or 19-nortestosterone which is a synthetic biologically active metabolite of progestin desogestrel.[A37184] The first product including etonogestrel was developed by the Merck subsidiary Organon and FDA approved in 2001.[L5692]
Indications and Usage Etonogestrel is administered in subdermal implants as long-acting reversible contraception. It is known to be effective in postpartum insertion including breastfeeding women.[A175990] Etonogestrel is part of the long-acting contraceptive implants that prevent pregnancy. The implant's effect can remain for 5 years.[L5698]
Marketing Status approved; investigational
ATC Code G03AC08
DrugBank ID DB00294
KEGG ID D04104
MeSH ID C044815
PubChem ID 6917715
TTD Drug ID D02KIU
NDC Product Code 64918-1500; 78206-145; 71161-147; 63190-0260; 45541-1192; 60870-0475; 63190-0480; 64918-1906; 65089-0053
UNII 304GTH6RNH
Synonyms etonogestrel | 13-ethyl-17-hydroxy-11-methylene-18,19-dinor-17alpha-pregn-4-en-20-yn-3-one | 3-oxodesogestrel | 3-ketodesogestrel | 3-oxo desogestrel | 18,19-dinorpregn-4-en-20-yn-3-one, 13-ethyl-17-hydroxy-11-methylene-, (17-alpha)- | 3-keto-desogestrel | ORG-3236 | Implanon | nexplanon
Chemical Information
Molecular Formula C22H28O2
CAS Registry Number 54048-10-1
SMILES CCC12CC(=C)C3C(C1CCC2(C#C)O)CCC4=CC(=O)CCC34
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Implant site pruritus23.03.12.013; 12.07.02.060; 08.02.02.0600.093914%Not Available
Implant site rash23.03.13.026; 08.02.02.061; 12.07.02.0610.027998%Not Available
Implant site scar23.03.11.033; 12.07.02.062; 08.02.02.0620.053598%Not Available
Implant site swelling12.07.02.063; 08.02.02.0630.071887%Not Available
Implant site thrombosis08.02.02.064; 24.01.01.041; 12.07.02.0640.000235%Not Available
Implant site urticaria23.04.02.016; 12.07.02.066; 10.01.06.016; 08.02.02.0660.011143%Not Available
Implant site vesicles12.07.02.067; 08.02.02.067; 23.03.01.0350.012624%Not Available
Implant site warmth12.07.02.068; 08.02.02.0680.010814%Not Available
Injection site scab08.02.03.069; 23.03.03.088; 12.07.03.0690.000799%Not Available
Intercostal neuralgia17.02.07.0250.000235%Not Available
Intermenstrual bleeding21.01.01.0150.219751%Not Available
Lactation insufficiency21.05.02.006; 18.06.02.0060.002821%Not Available
Limb mass15.03.05.0190.001434%Not Available
Lung opacity22.12.01.0060.000235%Not Available
Medical device site bruise08.07.01.017; 24.07.06.031; 23.03.11.038; 12.02.21.0010.000517%Not Available
Medical device site discomfort12.02.21.005; 08.07.01.0210.038788%Not Available
Medical device site fibrosis12.02.21.010; 08.07.01.0260.000917%Not Available
Medical device site granuloma08.07.01.027; 23.03.15.014; 12.02.21.0110.000353%Not Available
Medical device site movement impairment12.02.21.020; 08.07.01.0360.001434%Not Available
Medical device site reaction12.02.21.022; 08.07.01.0380.000517%Not Available
Medical device site scab23.03.03.092; 12.02.21.023; 08.07.01.0390.001834%Not Available
Morning sickness18.02.02.022; 07.01.07.0180.003432%Not Available
Perinatal depression19.15.01.011; 18.06.03.0030.000752%Not Available
Pregnancy on contraceptive18.08.01.0040.001998%Not Available
Pregnancy with implant contraceptive18.08.01.006; 08.07.04.0030.122358%Not Available
Procedural failure08.06.01.0440.000799%Not Available
Reaction to excipient10.01.01.0420.000353%Not Available
Superficial vein thrombosis24.01.02.0160.000917%Not Available
Therapeutic product ineffective08.06.01.0570.000917%Not Available
Unwanted pregnancy18.08.01.0080.000235%Not Available
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