| Pharmaceutical Information |
| Drug Name |
Ethacrynate sodium |
| Drug ID |
BADD_D00839 |
| Description |
A compound that inhibits symport of sodium, potassium, and chloride primarily in the ascending limb of Henle, but also in the proximal and distal tubules. This pharmacological action results in excretion of these ions, increased urinary output, and reduction in extracellular fluid. This compound has been classified as a loop or high ceiling diuretic. |
| Indications and Usage |
For the treatment of high blood pressure and edema caused by diseases like congestive heart failure, liver failure, and kidney failure. |
| Marketing Status |
Prescription; Discontinued |
| ATC Code |
C03CC01 |
| DrugBank ID |
DB00903
|
| KEGG ID |
D04079
|
| MeSH ID |
D004976
|
| PubChem ID |
23668825
|
| TTD Drug ID |
D06TNL
|
| NDC Product Code |
63552-145; 70771-1106; 42023-157; 14474-042; 65571-0026; 68382-246; 25010-210; 42413-0062; 69315-701 |
| Synonyms |
Ethacrynic Acid | Acid, Ethacrynic | Etacrynic Acid | Acid, Etacrynic | Ethacrinic Acid | Acid, Ethacrinic | Hydromedin | Edecrin | Ethacrynate Sodium | Sodium, Ethacrynate | Ethacrynic Acid, Sodium Salt |
|
| Chemical Information |
| Molecular Formula |
C13H11Cl2NaO4 |
| CAS Registry Number |
6500-81-8 |
| SMILES |
CCC(=C)C(=O)C1=C(C(=C(C=C1)OCC(=O)[O-])Cl)Cl.[Na+] |
| Chemical Structure |
|
|
| ADR Related Proteins Induced by Drug |
| ADR Term |
Protein Name |
UniProt AC |
TTD Target ID |
PMID |
| Not Available | Not Available | Not Available | Not Available | Not Available |
|
| ADRs Induced by Drug |
|
| ADR Term |
ADReCS ID |
ADR Frequency (FAERS)
|
ADR Severity Grade (FAERS)
|
ADR Severity Grade (CTCAE)
|
| Vision blurred | 17.17.01.010; 06.02.06.007 | - | - | | | Vomiting | 07.01.07.003 | - | - | | | Decreased appetite | 08.01.09.028; 14.03.01.005 | - | - | |
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