Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Estropipate
Drug ID BADD_D00836
Description Estrone sulfate (as estropipate) is a form of estrogen. It has several uses such as: alleviate symptoms of menopause as hormone replacement therapy, treatment some types of infertility, treatment of some conditions leading to underdevelopment of female sexual characteristics, treatment of vaginal atrophy, treatment of some types of breast cancer (particularly in men and postmenopausal women), treatment of prostate cancer and prevention of osteoporosis.
Indications and Usage Estropipate is used for the treatment of moderate to severe vasomotor symptoms associated with the monopause, and moderate to severe symptoms of vulval and vaginal atrophy associated with the menopause. It is also used to treat hypoestrogenism due to hypogonadism, castration or primary ovarian failure, and prevent postmenopausal osteoporosis.
Marketing Status Prescription; Discontinued
ATC Code G03CA07; G03CC04
DrugBank ID DB04574
KEGG ID D00948
MeSH ID C009927
PubChem ID 5284555
TTD Drug ID D03IUY
NDC Product Code 64918-0106; 12875-9998
Synonyms estropipate | piperazine estrone sulfate | estra-1,3,5(10)-trien-17-one, 3-(sulfooxy)-, compd. with piperazine (1:1) | Ogen | Harmogen | Genoral | Harmonet | Ortho-Est
Chemical Information
Molecular Formula C22H32N2O5S
CAS Registry Number 7280-37-7
SMILES CC12CCC3C(C1CCC2=O)CCC4=C3C=CC(=C4)OS(=O)(=O)O.C1CNCCN1
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.001--Not Available
Abdominal distension07.01.04.001--
Abdominal pain07.01.05.002--
Affective disorder19.04.04.001--Not Available
Alopecia23.02.02.001--
Anaphylactic reaction10.01.07.001; 24.06.03.006--
Anaphylactic shock24.06.02.004; 10.01.07.002--Not Available
Anaphylactoid reaction24.06.03.007; 10.01.07.003--Not Available
Angioedema23.04.01.001; 10.01.05.009--Not Available
Arthralgia15.01.02.001--
Asthma22.03.01.002; 10.01.03.010--Not Available
Bladder pain20.02.02.001--Not Available
Blister23.03.01.001; 12.01.06.002--Not Available
Blood pressure increased13.14.03.005--Not Available
Blood triglycerides13.12.03.004--Not Available
Breast cancer16.10.01.001; 21.05.01.003--Not Available
Breast discharge21.05.05.001--Not Available
Breast enlargement21.05.04.001--Not Available
Breast swelling21.05.05.008--Not Available
Breast tenderness21.05.05.004--Not Available
Carbohydrate tolerance decreased13.02.02.003--Not Available
Cardiovascular disorder24.03.02.009; 02.01.01.001--Not Available
Cerebrovascular accident24.03.05.001; 17.08.01.007--
Uterine cervical erosion21.06.01.006--Not Available
Chloasma23.05.01.001; 18.08.02.002--Not Available
Chorea17.01.01.001--Not Available
Contact lens intolerance06.01.01.003--Not Available
Coronary artery thrombosis24.01.05.002; 02.02.01.007--Not Available
Cystitis20.03.02.002; 11.01.14.001--
Dementia19.20.02.001; 17.03.01.001--Not Available
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