| Drug Name |
Escitalopram oxalate |
| Drug ID |
BADD_D00810 |
| Description |
Escitalopram is a selective serotonin re-uptake inhibitor (SSRI) and the S-enantiomer of racemic [citalopram].[A185420] It is used to restore serotonergic function in the treatment of depression and anxiety.[L8513,L8516,L8522] Escitalopram is approximately 150 times more potent than citalopram’s R-enantiomer and is responsible for the vast majority of citalopram’s clinical activity, with some evidence suggesting that the R-enantiomer of racemic citalopram actively dampens the activity of escitalopram rather than existing simply as an inactive enantiomer.[A39738,A185819] Amongst SSRIs, escitalopram exerts the highest degree of selectivity for the serotonin transporter (SERT) relative to other off-targets which may explain its lower rates of adverse effects as compared to other agents in this class.[A185726] Escitalopram also differentiates itself from other SSRIs via allosteric action on its target - this may be the mechanism responsible for its observed superior efficacy and faster onset compared to other SSRIs.[A185825,A185726,A185822] |
| Indications and Usage |
Labeled indications include major depressive disorder (MDD) and generalized anxiety disorder (GAD). Unlabeled indications include treatment of mild dementia-associated agitation in nonpsychotic patients. |
| Marketing Status |
Prescription |
| ATC Code |
N06AB10 |
| DrugBank ID |
DB01175
|
| KEGG ID |
D02567
|
| MeSH ID |
D000089983
|
| PubChem ID |
146571
|
| TTD Drug ID |
D08RBC
|
| NDC Product Code |
71335-0322; 68071-3265; 55289-828; 43063-761; 71205-313; 55111-944; 58032-0134; 70966-0032; 70934-089; 71052-647; 65862-373; 59746-279; 65372-1143; 68084-617; 68084-618; 65862-411; 0904-6427; 61919-139; 68071-2597; 45562-1130; 59746-280; 71205-168; 65372-1116; 22365-115; 53104-7565; 65862-375; 65015-886; 70934-163; 71205-193; 55154-6893; 70518-1291; 68788-6978; 0456-2021; 65162-019; 13668-136; 17856-0551; 51672-1348; 50090-5112; 65162-020; 65862-374; 0904-6426; 68001-197; 16571-769; 31722-569; 68001-196; 13668-135; 55154-7288; 70934-060; 68554-0007; 71335-0658; 65862-248; 68001-195; 51686-0011; 64220-109; 0456-2006; 0456-2011; 71335-0685; 72761-009; 65162-021; 59746-281; 61919-227; 13668-137; 50090-5131; 55289-768; 63629-8042; 63629-2981; 65691-0066; 70518-0791; 45865-996; 42708-077 |
| Synonyms |
Escitalopram | Escitalopram Oxalate | Lexapro |
