Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Escitalopram
Drug ID BADD_D00809
Description Escitalopram is a selective serotonin re-uptake inhibitor (SSRI) and the S-enantiomer of racemic [citalopram].[A185420] It is used to restore serotonergic function in the treatment of depression and anxiety.[L8513,L8516,L8522] Escitalopram is approximately 150 times more potent than citalopram’s R-enantiomer and is responsible for the vast majority of citalopram’s clinical activity, with some evidence suggesting that the R-enantiomer of racemic citalopram actively dampens the activity of escitalopram rather than existing simply as an inactive enantiomer.[A39738,A185819] Amongst SSRIs, escitalopram exerts the highest degree of selectivity for the serotonin transporter (SERT) relative to other off-targets which may explain its lower rates of adverse effects as compared to other agents in this class.[A185726] Escitalopram also differentiates itself from other SSRIs via allosteric action on its target - this may be the mechanism responsible for its observed superior efficacy and faster onset compared to other SSRIs.[A185825,A185726,A185822]
Indications and Usage Labeled indications include major depressive disorder (MDD) and generalized anxiety disorder (GAD). Unlabeled indications include treatment of mild dementia-associated agitation in nonpsychotic patients.
Marketing Status Prescription
ATC Code N06AB10
DrugBank ID DB01175
KEGG ID D07913
MeSH ID D000089983
PubChem ID 146570
TTD Drug ID D08RBC
NDC Product Code 68071-2051; 68071-2035; 51655-284; 68071-4984; 68071-5248; 70518-2472; 65162-705; 42708-023; 70518-1110; 0456-2010; 63187-281; 71610-425; 61919-652; 63187-217; 50090-3331; 16729-168; 55700-847; 69097-849; 45865-699; 76282-249; 71335-1002; 0456-2005; 43547-281; 67296-1421; 0615-8349; 68001-455; 70518-2597; 63629-8241; 70518-3151; 68071-4985; 67296-1200; 33342-053; 51655-449; 53002-1438; 70934-112; 70771-1146; 68788-7510; 68788-7559; 16729-170; 0615-8348; 70518-1876; 70518-2317; 43063-661; 70518-2430; 71335-1307; 43547-282; 50090-4915; 70771-1147; 55700-818; 0615-8366; 68001-456; 71335-1571; 16729-169; 69097-848; 71335-1187; 70518-1805; 70518-1785; 67296-1689; 68645-520; 60760-393; 53002-2438; 50090-4363; 76282-251; 71205-344; 71335-1241; 50090-1930; 60760-170; 0615-8365; 68788-7461; 42708-022; 72789-194; 54838-551; 76282-250; 68788-7912; 0456-2020; 69097-847; 68001-454; 68645-519; 50090-5312; 67296-1597; 71205-325; 53002-1453; 43547-280; 71335-1030; 0615-8350; 68071-3069; 50090-2196; 67296-1408; 71610-534; 70771-1145; 71335-2058
Synonyms Escitalopram | Escitalopram Oxalate | Lexapro
Chemical Information
Molecular Formula C20H21FN2O
CAS Registry Number 128196-01-0
SMILES CN(C)CCCC1(C2=C(CO1)C=C(C=C2)C#N)C3=CC=C(C=C3)F
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Pelvic kidney20.01.06.010; 03.06.01.0120.000237%Not Available
Persecutory delusion19.10.01.0070.000190%Not Available
Pulmonary artery atresia03.07.09.007; 02.08.01.0100.000025%Not Available
Pulmonary artery stenosis24.04.09.011; 22.06.03.0060.000095%Not Available
Pulmonary artery stenosis congenital24.04.09.012; 22.06.03.007; 03.07.09.0080.000570%Not Available
Pulmonary valve stenosis02.07.04.0050.000142%Not Available
Renal dysplasia20.01.06.013; 03.06.01.0130.000237%Not Available
Respiratory rate increased13.15.01.0040.000095%Not Available
Sexual inhibition19.08.04.0080.000095%Not Available
Small for dates baby18.04.02.0020.000997%Not Available
Transposition of the great vessels24.03.03.042; 03.07.08.009; 02.08.03.0050.000807%Not Available
Truncus arteriosus persistent03.07.08.010; 02.08.02.009; 24.03.03.0430.000025%Not Available
Violence-related symptom19.05.01.0220.000095%Not Available
Plagiocephaly15.11.02.009; 03.11.02.0090.000095%Not Available
Umbilical cord abnormality18.04.14.0030.000095%Not Available
Cerebral ventricle dilatation17.11.01.0130.000095%Not Available
Congenital tricuspid valve atresia03.07.05.011; 02.07.05.0020.000190%Not Available
Macrocephaly15.11.02.007; 03.11.02.0070.000025%Not Available
Right ventricular hypertrophy02.04.02.0340.000095%Not Available
Tongue biting17.02.05.064; 12.01.09.019; 07.14.01.0130.000380%Not Available
Congenital pulmonary hypertension22.11.01.006; 18.04.09.005; 03.16.06.0010.000190%Not Available
Retrognathia15.10.05.0080.000237%Not Available
Congenital pulmonary valve atresia03.07.05.009; 02.07.04.0030.000095%Not Available
Peripheral artery occlusion24.04.03.0220.000095%Not Available
Maternal condition affecting foetus18.03.03.0080.000095%Not Available
Right ventricular dysfunction02.04.02.0330.000095%
Negative thoughts19.15.02.0120.000142%Not Available
Sopor19.02.04.002; 17.02.04.0210.002565%Not Available
Cerebellar haematoma24.07.04.022; 17.08.01.0450.000142%Not Available
Pyelocaliectasis20.01.06.0110.000095%Not Available
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