Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Ertapenem sodium
Drug ID BADD_D00803
Description Ertapenem is a carbapenem antibiotic drug that is marketed under the trade name Invanz by Merck & Co. pharmaceutical company. It is structurally similar to [meropenem] and possesses a 1-beta-methyl group.
Indications and Usage For the treatment the following moderate to severe infections caused by susceptible isolates of the designated microorganisms: (1) complicated intra-abdominal infections due to Escherichia coli, Clostridium clostridioforme, Eubacterium lentum, Peptostreptococcus species, Bacteroides fragilis, Bacteroides distasonis, Bacteroides ovatus, Bacteroides thetaiotaomicron, or Bacteroides uniformis, (2) complicated skin and skin structure infections, including diabetic foot infections without osteomyelitis due to Staphylococcus aureus (methicillin susceptible isolates only), Streptococcus agalactiae, Streptococcus pyogenes, Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Bacteroides fragilis, Peptostreptococcus species, Porphyromonas asaccharolytica, or Prevotella bivia, (3) community acquired pneumonia due to Streptococcus pneumoniae (penicillin susceptible isolates only) including cases with concurrent bacteremia, Haemophilus influenzae (beta-lactamase negative isolates only), or Moraxella catarrhalis, (4) complicated urinary tract infections including pyelonephritis due to Escherichia coli, including cases with concurrent bacteremia, or Klebsiella pneumoniae, (5) acute pelvic infections including postpartum endomyometritis, septic abortion and post surgical gynecologic infections due to Streptococcus agalactiae, Escherichia coli, Bacteroides fragilis, Porphyromonas asaccharolytica, Peptostreptococcus species, or Prevotella bivia.
Marketing Status Prescription
ATC Code J01DH03
DrugBank ID DB00303
KEGG ID D04049
MeSH ID D000077727
PubChem ID 23674512
TTD Drug ID D0Q1MS
NDC Product Code 44647-005; 42023-221; 68083-351; 0143-9398; 63323-823; 44647-051; 0006-3843; 72266-159; 59651-190; 68001-408; 60505-6196; 69806-0003
Synonyms Ertapenem | Invanoz | Invanz | Ertapenem Sodium
Chemical Information
Molecular Formula C22H24N3NaO7S
CAS Registry Number 153773-82-1
SMILES CC1C2C(C(=O)N2C(=C1SC3CC(NC3)C(=O)NC4=CC=CC(=C4)C(=O)[O-])C(=O)O)C(C)O.[Na+]
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Vulvovaginal candidiasis21.14.02.003; 11.03.03.005--Not Available
Vulvovaginitis11.01.10.003; 21.14.02.005--Not Available
Weight decreased13.15.01.005--
Wheezing22.03.01.009--
Wound dehiscence12.02.05.003--
Wound infection12.01.08.012; 11.01.08.010--
Mental status changes19.07.01.001--Not Available
Wound secretion08.01.03.035; 12.01.08.007--Not Available
Infusion site erythema23.03.06.016; 12.07.05.009; 08.02.05.008--Not Available
Anastomotic leak12.02.05.013--Not Available
Incision site haemorrhage24.07.01.022; 12.02.05.014--Not Available
Platelet count increased13.01.04.002--Not Available
Infusion site pain12.07.05.002; 08.02.05.014--Not Available
Infusion site pruritus23.03.12.006; 12.07.05.005; 08.02.05.004--Not Available
Wound complication12.01.08.010--
Vulvovaginal pruritus23.03.12.009; 21.08.02.004--Not Available
Incision site complication12.02.05.012--Not Available
Blood alkaline phosphatase increased13.04.02.004--
Urine output increased13.13.03.002--Not Available
Induration08.01.03.020--Not Available
Abdominal abscess11.01.07.006; 07.19.02.002--Not Available
Decreased appetite14.03.01.005; 08.01.09.028--
Urinary tract obstruction20.08.01.004--
Renal impairment20.01.03.010--Not Available
Gastrointestinal stoma complication12.02.16.001; 07.11.01.009--
Oropharyngeal discomfort22.02.05.027; 07.05.05.008--Not Available
Bladder dysfunction20.03.03.002--Not Available
Drug reaction with eosinophilia and systemic symptoms23.03.05.005; 10.01.01.021--Not Available
Candida infection11.03.03.021--
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