Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Epoprostenol
Drug ID BADD_D00788
Description A prostaglandin that is a powerful vasodilator and inhibits platelet aggregation. It is biosynthesized enzymatically from prostaglandin endoperoxides in human vascular tissue. The sodium salt has been also used to treat primary pulmonary hypertension.
Indications and Usage For the long-term intravenous treatment of primary pulmonary hypertension and pulmonary hypertension associated with the scleroderma spectrum of disease in NYHA Class III and Class IV patients who do not respond adequately to conventional therapy.
Marketing Status Prescription
ATC Code B01AC09
DrugBank ID DB01240
KEGG ID D00106
MeSH ID D011464
PubChem ID 5282411
TTD Drug ID D0V0IX
NDC Product Code 62756-059; 66215-402; 66215-403; 62287-123; 62756-060
Synonyms Epoprostenol | Epoprostanol | Prostaglandin I2 | Prostacyclin | Prostaglandin I(2) | Veletri | Epoprostenol Sodium | Epoprostenol Sodium Salt, (5Z,9alpha,11alpha,13E,15S)-Isomer | Flolan
Chemical Information
Molecular Formula C20H32O5
CAS Registry Number 35121-78-9
SMILES CCCCCC(C=CC1C(CC2C1CC(=CCCCC(=O)O)O2)O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Photophobia17.17.02.006; 06.01.01.0040.000371%
Platelet count decreased13.01.04.0010.003153%
Pleural effusion22.05.02.0020.002226%
Pneumonia22.07.01.003; 11.01.09.0030.017808%Not Available
Pneumothorax22.05.02.0030.001669%
Polyuria20.02.03.0020.000371%Not Available
Portal hypertension24.08.06.001; 09.01.06.0060.000371%
Premature baby18.04.02.0010.002782%Not Available
Premature delivery18.07.01.0060.000556%
Presyncope24.06.02.010; 17.02.05.009; 02.01.02.0070.000556%
Productive cough22.02.03.0050.000927%
Pruritus23.03.12.001--
Pulmonary arterial pressure increased13.14.03.0250.001484%Not Available
Pulmonary embolism24.01.06.001; 22.06.02.001--Not Available
Pulmonary haemorrhage24.07.01.016; 22.02.04.0030.000387%
Pulmonary hypertension24.08.03.002; 22.06.01.0010.001742%
Pulmonary oedema22.01.03.003; 02.05.02.0030.002597%
Pulmonary veno-occlusive disease24.01.06.008; 22.06.03.0030.000339%Not Available
Pyrexia08.05.02.0030.008533%
Rash23.03.13.0010.006121%Not Available
Rash erythematous23.03.06.0030.001298%Not Available
Rash generalised23.03.13.0020.001298%Not Available
Rash macular23.03.13.0030.000742%Not Available
Rash papular23.03.13.0170.000742%Not Available
Rash pruritic23.03.12.0020.001298%Not Available
Rectal haemorrhage24.07.02.018; 07.12.03.001--
Rectal prolapse07.03.01.0050.000371%Not Available
Red blood cell count decreased13.01.05.007--Not Available
Renal disorder20.01.02.0020.001484%Not Available
Renal failure20.01.03.0050.001113%Not Available
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