Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Epoprostenol
Drug ID BADD_D00788
Description A prostaglandin that is a powerful vasodilator and inhibits platelet aggregation. It is biosynthesized enzymatically from prostaglandin endoperoxides in human vascular tissue. The sodium salt has been also used to treat primary pulmonary hypertension.
Indications and Usage For the long-term intravenous treatment of primary pulmonary hypertension and pulmonary hypertension associated with the scleroderma spectrum of disease in NYHA Class III and Class IV patients who do not respond adequately to conventional therapy.
Marketing Status Prescription
ATC Code B01AC09
DrugBank ID DB01240
KEGG ID D00106
MeSH ID D011464
PubChem ID 5282411
TTD Drug ID D0V0IX
NDC Product Code 62756-059; 66215-402; 66215-403; 62287-123; 62756-060
Synonyms Epoprostenol | Epoprostanol | Prostaglandin I2 | Prostacyclin | Prostaglandin I(2) | Veletri | Epoprostenol Sodium | Epoprostenol Sodium Salt, (5Z,9alpha,11alpha,13E,15S)-Isomer | Flolan
Chemical Information
Molecular Formula C20H32O5
CAS Registry Number 35121-78-9
SMILES CCCCCC(C=CC1C(CC2C1CC(=CCCCC(=O)O)O2)O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Chest pain02.02.02.011; 22.02.08.003; 08.01.08.0020.009831%Not Available
Chills08.01.09.001; 15.05.03.0160.002411%
Cholangitis09.02.01.0020.000097%Not Available
Cholecystitis09.03.01.0010.000371%
Cholelithiasis09.03.01.0020.000556%Not Available
Chronic obstructive pulmonary disease22.03.01.0070.000194%Not Available
Circulatory collapse24.06.02.0010.000371%Not Available
Collagen disorder15.06.01.005; 10.04.04.002--Not Available
Colon cancer16.13.01.001; 07.21.01.0010.000097%Not Available
Confusional state19.13.01.001; 17.02.03.005--
Constipation07.02.02.001--
Cough22.02.03.0010.005379%
Crying19.04.02.002; 17.02.05.013; 08.01.03.005; 12.02.11.0010.000371%Not Available
Cyanosis24.03.01.007; 22.02.02.007; 02.01.02.0020.000097%
Cystitis20.03.02.002; 11.01.14.0010.000371%
Deafness04.02.01.0010.000371%Not Available
Death08.04.01.0010.013985%
Dehydration14.05.05.0010.005565%
Delirium19.13.02.0010.000927%
Depressed level of consciousness17.02.04.002--
Depressed mood19.15.02.001--Not Available
Depression19.15.01.001--
Dermatitis23.03.04.002--Not Available
Dermatitis contact23.03.04.004; 12.03.01.040; 10.01.01.0030.002411%Not Available
Diabetes mellitus05.06.01.001; 14.06.01.001--Not Available
Diarrhoea07.02.01.0010.023929%
Dilatation ventricular02.04.02.0260.000371%Not Available
Disorientation17.02.05.015; 19.13.01.0020.000556%Not Available
Diverticulitis11.01.07.003; 07.10.02.0010.000556%Not Available
Dizziness02.01.02.004; 24.06.02.007; 17.02.05.0030.009460%
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