Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Epoprostenol
Drug ID BADD_D00788
Description A prostaglandin that is a powerful vasodilator and inhibits platelet aggregation. It is biosynthesized enzymatically from prostaglandin endoperoxides in human vascular tissue. The sodium salt has been also used to treat primary pulmonary hypertension.
Indications and Usage For the long-term intravenous treatment of primary pulmonary hypertension and pulmonary hypertension associated with the scleroderma spectrum of disease in NYHA Class III and Class IV patients who do not respond adequately to conventional therapy.
Marketing Status Prescription
ATC Code B01AC09
DrugBank ID DB01240
KEGG ID D00106
MeSH ID D011464
PubChem ID 5282411
TTD Drug ID D0V0IX
NDC Product Code 62756-059; 66215-402; 66215-403; 62287-123; 62756-060
Synonyms Epoprostenol | Epoprostanol | Prostaglandin I2 | Prostacyclin | Prostaglandin I(2) | Veletri | Epoprostenol Sodium | Epoprostenol Sodium Salt, (5Z,9alpha,11alpha,13E,15S)-Isomer | Flolan
Chemical Information
Molecular Formula C20H32O5
CAS Registry Number 35121-78-9
SMILES CCCCCC(C=CC1C(CC2C1CC(=CCCCC(=O)O)O2)O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Hepatic cancer16.07.02.004; 09.04.02.0080.000145%Not Available
Hepatocellular carcinoma16.07.02.005; 09.04.02.010--Not Available
Foetal heart rate deceleration abnormality18.03.02.012; 02.03.02.0220.000371%Not Available
Multiple organ dysfunction syndrome08.01.03.0570.000532%
Anal incontinence17.05.01.021; 07.01.06.0290.000371%
Biopsy bone marrow13.01.08.0020.000742%Not Available
Biopsy liver13.03.02.0020.000371%Not Available
Catheterisation cardiac13.14.07.0030.001298%Not Available
Concomitant disease aggravated08.01.03.0630.000242%Not Available
Normal newborn18.08.06.0010.000371%Not Available
Oxygen saturation abnormal13.02.01.0280.000742%Not Available
Purulent discharge11.01.08.061; 08.01.03.0760.000371%Not Available
Systemic sclerosis24.03.03.041; 23.03.02.021; 15.06.01.019; 10.04.07.006; 07.11.02.0080.000097%Not Available
Tri-iodothyronine increased13.10.06.0210.000927%Not Available
Vascular injury24.11.01.001; 12.01.11.0040.000371%Not Available
Concomitant disease progression08.01.03.0640.000371%Not Available
Terminal state08.01.03.0790.000371%Not Available
Live birth18.08.02.0070.000742%Not Available
Spinal cord ischaemia24.04.06.040; 17.10.01.0180.000927%Not Available
Right ventricular hypertrophy02.04.02.0340.000371%Not Available
Brain natriuretic peptide increased13.02.04.0110.000371%Not Available
Clostridium difficile infection11.02.02.0090.002040%Not Available
Thyroxine free increased13.10.06.0180.000927%Not Available
Gastric infection11.01.07.008; 07.19.03.0030.000371%Not Available
Cardiac valve vegetation11.01.16.004; 02.07.02.0060.000097%Not Available
Oxygen consumption increased13.02.01.0270.001113%Not Available
Arterial haemorrhage24.07.01.0630.000371%Not Available
Paracentesis13.18.01.0090.001855%Not Available
Acute right ventricular failure02.05.03.0030.000371%Not Available
Delivery18.08.02.0060.000742%Not Available
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