Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Epoprostenol
Drug ID BADD_D00788
Description A prostaglandin that is a powerful vasodilator and inhibits platelet aggregation. It is biosynthesized enzymatically from prostaglandin endoperoxides in human vascular tissue. The sodium salt has been also used to treat primary pulmonary hypertension.
Indications and Usage For the long-term intravenous treatment of primary pulmonary hypertension and pulmonary hypertension associated with the scleroderma spectrum of disease in NYHA Class III and Class IV patients who do not respond adequately to conventional therapy.
Marketing Status approved
ATC Code B01AC09
DrugBank ID DB01240
KEGG ID D00106
MeSH ID D011464
PubChem ID 5282411
TTD Drug ID D0V0IX
NDC Product Code 66215-402; 62756-060; 66215-403; 62287-123; 62756-059
UNII DCR9Z582X0
Synonyms Epoprostenol | Epoprostanol | Prostaglandin I2 | Prostacyclin | Prostaglandin I(2) | Veletri | Epoprostenol Sodium | Epoprostenol Sodium Salt, (5Z,9alpha,11alpha,13E,15S)-Isomer | Flolan
Chemical Information
Molecular Formula C20H32O5
CAS Registry Number 35121-78-9
SMILES CCCCCC(C=CC1C(CC2C1CC(=CCCCC(=O)O)O2)O)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.0010.001357%Not Available
Abdominal distension07.01.04.0010.001308%
Abdominal pain07.01.05.0020.001867%
Abdominal pain upper07.01.05.0030.001308%
Abnormal faeces07.01.03.0010.000181%Not Available
Acidosis14.01.03.0020.000082%
Acute respiratory failure22.02.06.001; 14.01.04.0040.000164%Not Available
Agitation17.02.05.012; 19.06.02.001--
Anaemia01.03.02.001--
Anaphylactic shock24.06.02.004; 10.01.07.002--Not Available
Angina pectoris24.04.04.002; 02.02.02.0020.000123%
Anuria20.01.03.0020.000082%Not Available
Anxiety19.06.02.002--
Application site erythema23.03.06.005; 12.07.01.001; 08.02.01.0010.000362%Not Available
Application site irritation12.07.01.003; 08.02.01.0030.000304%Not Available
Application site pain08.02.01.004; 12.07.01.004--Not Available
Application site pruritus23.03.12.004; 12.07.01.005; 08.02.01.0050.000444%Not Available
Application site rash23.03.13.008; 12.07.01.016; 08.02.01.0160.000304%Not Available
Application site reaction08.02.01.006; 12.07.01.0060.000123%Not Available
Arrhythmia02.03.02.0010.000206%Not Available
Arterial thrombosis24.01.01.0020.000082%Not Available
Arthralgia15.01.02.0010.001505%
Arthritis15.01.01.001--
Ascites07.07.01.001; 02.05.04.002; 09.01.05.0030.002138%
Asthenia08.01.01.0010.002410%Not Available
Asthma10.01.03.010; 22.03.01.0020.000164%Not Available
Atelectasis22.01.02.0010.000082%
Atrial fibrillation02.03.03.0020.001045%
Atrial flutter02.03.03.0030.000181%
Back pain15.03.04.0050.001489%
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