Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Epoprostenol
Drug ID BADD_D00788
Description A prostaglandin that is a powerful vasodilator and inhibits platelet aggregation. It is biosynthesized enzymatically from prostaglandin endoperoxides in human vascular tissue. The sodium salt has been also used to treat primary pulmonary hypertension.
Indications and Usage For the long-term intravenous treatment of primary pulmonary hypertension and pulmonary hypertension associated with the scleroderma spectrum of disease in NYHA Class III and Class IV patients who do not respond adequately to conventional therapy.
Marketing Status Prescription
ATC Code B01AC09
DrugBank ID DB01240
KEGG ID D00106
MeSH ID D011464
PubChem ID 5282411
TTD Drug ID D0V0IX
NDC Product Code 62756-059; 66215-402; 66215-403; 62287-123; 62756-060
Synonyms Epoprostenol | Epoprostanol | Prostaglandin I2 | Prostacyclin | Prostaglandin I(2) | Veletri | Epoprostenol Sodium | Epoprostenol Sodium Salt, (5Z,9alpha,11alpha,13E,15S)-Isomer | Flolan
Chemical Information
Molecular Formula C20H32O5
CAS Registry Number 35121-78-9
SMILES CCCCCC(C=CC1C(CC2C1CC(=CCCCC(=O)O)O2)O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.0010.002411%Not Available
Abdominal distension07.01.04.0010.003339%
Abdominal pain07.01.05.0020.006307%
Abdominal pain lower07.01.05.010--Not Available
Abdominal pain upper07.01.05.0030.003895%
Abnormal faeces07.01.03.0010.000371%Not Available
Acute respiratory failure22.02.06.001; 14.01.04.0040.000145%Not Available
Agitation19.06.02.001; 17.02.05.012--
Alopecia23.02.02.001--
Ammonia increased13.03.01.0230.000742%Not Available
Anaemia01.03.02.0010.003153%
Anaphylactic reaction24.06.03.006; 10.01.07.001--
Anaphylactic shock24.06.02.004; 10.01.07.002--Not Available
Angina pectoris24.04.04.002; 02.02.02.002--
Anuria20.01.03.0020.000371%Not Available
Anxiety19.06.02.002--
Application site pain12.07.01.004; 08.02.01.004--Not Available
Arrhythmia02.03.02.001--Not Available
Arthralgia15.01.02.0010.003710%
Arthritis15.01.01.001--
Ascites02.05.04.002; 09.01.05.003; 07.07.01.0010.008347%
Aspiration pleural cavity13.19.03.0020.000371%Not Available
Asthenia08.01.01.0010.007605%Not Available
Asthma22.03.01.002; 10.01.03.0100.000742%Not Available
Atrial fibrillation02.03.03.0020.002782%
Back pain15.03.04.0050.004823%
Bacteraemia11.01.11.0010.001298%
Basedow's disease10.04.08.004; 06.09.04.003; 05.02.02.0030.003153%Not Available
Blister23.03.01.001; 12.01.06.0020.000927%Not Available
Blood creatinine increased13.13.01.004--
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