Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Ephedrine sulfate
Drug ID BADD_D00778
Description Ephedrine was first described in western literature in 1888, as a naturally occurring component of the ephedra plant, along with [pseudoephedrine].[A193698] Ephedrine is an adrenergic receptor agonist used for its vasoconstrictive, positive chronotropic, and positive inotropic effects.[L12972] Ephedrine and [phenylephrine] are still commonly used to treat hypotension but their use in other indications has decreased due to the development of more selective adrenergic agonists.[A193701,A193704,L12975] Ephedrine was granted a type 7 FDA Approval on 29 April 2016.[L12975]
Indications and Usage Ephedrine commonly used as a stimulant, appetite suppressant, concentration aid, decongestant, and to treat hypotension associated with anaesthesia.
Marketing Status Prescription
ATC Code C01CA26; R01AA03; R01AB05; R03CA02; S01FB02
DrugBank ID DB01364
KEGG ID D04018
MeSH ID D004809
PubChem ID 5359318
TTD Drug ID D0LG8E
NDC Product Code 71872-7276; 47621-315; 17478-515; 57218-511; 72572-151; 65219-257; 17478-517; 51662-1325; 68083-495; 71872-7257; 71872-7269; 51754-4200; 17478-415; 0781-3269; 70121-1637; 65724-4302; 42023-196; 17478-955; 51754-4250; 57218-937; 49452-2730; 68225-079; 76014-005; 42023-216; 42023-243; 69536-250; 51927-1471; 55150-373; 0641-6238; 16714-037; 43598-725; 68001-330; 14789-250; 60646-104; 72572-150
Synonyms Ephedrine | Erythro Isomer of Ephedrine | Ephedrine Erythro Isomer | Sal-Phedrine | Sal Phedrine | SalPhedrine | Ephedrine Sulfate | Sulfate, Ephedrine | Ephedrine Hydrochloride | Hydrochloride, Ephedrine | Ephedrine Renaudin | Renaudin, Ephedrine
Chemical Information
Molecular Formula C20H32N2O6S
CAS Registry Number 134-72-5
SMILES CC(C(C1=CC=CC=C1)O)NC.CC(C(C1=CC=CC=C1)O)NC.OS(=O)(=O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Arrhythmia02.03.02.001--Not Available
Chest pain22.02.08.003; 08.01.08.002; 02.02.02.011--Not Available
Headache17.14.01.001--
Hyperhidrosis23.02.03.004; 08.01.03.028--
Insomnia19.02.01.002; 17.15.03.002--
Nausea07.01.07.001--
Nervousness19.06.02.003--Not Available
Palpitations02.01.02.003--
Tachycardia02.03.02.007--Not Available
Tremor17.01.06.002--
Vertigo04.04.01.003; 17.02.12.002--
Vomiting07.01.07.003--
Decreased appetite14.03.01.005; 08.01.09.028--
Urinary tract obstruction20.08.01.004--
Sphincter of Oddi dysfunction09.02.02.004; 07.18.02.002--Not Available
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