Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Eltrombopag
Drug ID BADD_D00759
Description Eltrombopag is used to treat low blood platelet counts in adults with chronic immune (idiopathic) thrombocytopenia (ITP), when certain other medicines, or surgery to remove the spleen, have not worked well enough. ITP is a condition that may cause unusual bruising or bleeding due to an abnormally low number of platelets in the blood. Eltrombopag has also been recently approved (late 2012) for the treatment of thrombocytopenia (low blood platelet counts) in patients with chronic hepatitis C to allow them to initiate and maintain interferon-based therapy.
Indications and Usage Thrombopoietin receptor agonists are pharmaceutical agents that stimulate platelet production in the bone marrow. In this, they differ from the previously discussed agents that act by attempting to curtail platelet destruction.
Marketing Status Prescription
ATC Code B02BX05
DrugBank ID DB06210
KEGG ID D03978
MeSH ID C520809
PubChem ID 135449332
TTD Drug ID D00PEH
NDC Product Code 47621-307
Synonyms eltrombopag | Revolade | SB-497 115 | Promacta
Chemical Information
Molecular Formula C25H22N4O4
CAS Registry Number 496775-61-2
SMILES CC1=C(C=C(C=C1)N2C(=O)C(=C(N2)C)N=NC3=CC=CC(=C3O)C4=CC(=CC=C4)C(=O)O)C
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Intervertebral disc protrusion15.10.01.0040.001634%Not Available
Contusion15.03.01.008; 12.01.06.001; 24.07.06.001; 23.03.11.0020.009802%
Musculoskeletal chest pain15.03.04.012; 22.09.01.001--
Deep vein thrombosis24.01.02.0030.010346%Not Available
Platelet count increased13.01.04.0020.034306%Not Available
Lymphatic disorder01.09.01.003--Not Available
Pruritus generalised23.03.12.003--Not Available
Musculoskeletal stiffness15.03.01.005--Not Available
Musculoskeletal discomfort15.03.04.0010.001089%Not Available
Transaminases increased13.03.01.015--Not Available
Haemorrhage24.07.01.0020.009257%Not Available
Pulmonary mass22.02.07.0040.001089%Not Available
Gastric disorder07.11.01.0030.002178%Not Available
Cognitive disorder19.21.02.001; 17.03.03.003--
Lung neoplasm malignant22.08.01.001; 16.19.02.0010.000426%Not Available
Blood alkaline phosphatase increased13.04.02.0040.001634%
Hepatic enzyme increased13.03.01.0190.006534%Not Available
Hot flush24.03.01.005; 21.02.02.001; 08.01.03.027--
Bladder disorder20.03.01.0020.001089%Not Available
Cardiac disorder02.01.01.003--Not Available
Connective tissue disorder15.06.01.006--Not Available
Feeding disorder19.09.01.003; 14.03.02.0030.001089%Not Available
Embolism24.01.01.0090.000284%
Infestation23.09.05.001; 11.09.01.001--Not Available
Limb discomfort15.03.04.0140.001089%Not Available
Malnutrition14.03.02.004--Not Available
Mediastinal disorder22.09.03.001--Not Available
Mental disorder19.07.01.002--Not Available
Upper limb fracture15.08.03.018; 12.04.01.0180.000284%Not Available
Decreased appetite14.03.01.005; 08.01.09.0280.015792%
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