Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Doxorubicin hydrochloride
Drug ID BADD_D00724
Description Doxorubicin is a cytotoxic anthracycline antibiotic isolated from cultures of Streptomyces peucetius var. caesius. Doxorubicin binds to nucleic acids, presumably by specific intercalation of the planar anthracycline nucleus with the DNA double helix.
Indications and Usage Doxorubicin is used to produce regression in disseminated neoplastic conditions like acute lymphoblastic leukemia, acute myeloblastic leukemia, Wilms’ tumor, neuroblastoma, soft tissue and bone sarcomas, breast carcinoma, ovarian carcinoma, transitional cell bladder carcinoma, thyroid carcinoma, gastric carcinoma, Hodgkin’s disease, malignant lymphoma and bronchogenic carcinoma in which the small cell histologic type is the most responsive compared to other cell types. Doxorubicin is also indicated for use as a component of adjuvant therapy in women with evidence of axillary lymph node involvement following resection of primary breast cancer.
Marketing Status Prescription; Discontinued
ATC Code L01DB01
DrugBank ID DB00997
KEGG ID D01275
MeSH ID D004317
PubChem ID 443939
TTD Drug ID D07VLY
NDC Product Code 0143-9093; 0143-9372; 43598-283; 49315-009; 43598-682; 45963-733; 16714-742; 47335-050; 0143-9547; 0338-0067; 62756-827; 17337-0260; 0338-0063; 0143-9371; 68001-345; 16714-001; 43598-683; 63323-883; 0143-9091; 27831-001; 0143-9275; 67457-436; 56161-101; 53183-7000; 63323-101; 0069-4004; 0143-9369; 0069-3034; 43598-541; 0143-9370; 58623-0029; 47335-049; 58623-0119; 0574-0930; 62756-826; 0143-9549; 68001-492; 68083-250; 0069-3033; 16714-856; 70710-1530; 0143-9087; 0143-9089; 0069-3031; 0069-4037; 77391-001; 12064-019; 72603-103; 0069-4015; 0143-9086; 72603-200; 0143-9084; 0143-9277; 0069-4026; 0143-9085; 0574-0931; 0143-9546; 68001-493; 49315-008; 0143-9088; 0143-9090; 70121-1219; 0143-9548; 68083-248; 0069-3032; 0143-9092; 70710-1531; 0069-3030; 68083-249; 70860-208
Synonyms Doxorubicin | Farmiblastina | Ribodoxo | Rubex | Adriamycin | Adriblastin | Adriblastine | Adriblastina | Adriablastine | Adriablastin | Adrimedac | DOXO-cell | DOXO cell | Urokit Doxo-cell | Urokit Doxo cell | Doxolem | Doxorubicin Hexal | Doxorubicin Hydrochloride | Hydrochloride, Doxorubicin | Doxorubicin NC | Doxorubicina Ferrer Farm | Doxorubicina Funk | Doxorubicina Tedec | Doxorubicine Baxter | Doxotec | Myocet | Onkodox
Chemical Information
Molecular Formula C27H29NO11.ClH
CAS Registry Number 25316-40-9
SMILES CC1C(C(CC(O1)OC2CC(CC3=C2C(=C4C(=C3O)C(=O)C5=C(C4=O)C(=CC=C5)OC)O)(C(=O)CO)O)N)O .Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
CardiotoxicityTroponin I, fast skeletal muscleP48788Not AvailableNot Available
CardiotoxicityCreatine kinase B-typeP07335Not AvailableNot Available
Cell deathCaspase-3P42574T57943Not Available
Cytogenetic investigationsDNA topoisomerase 1P11387T09826Not Available
Electrolyte imbalanceParathyroid hormone/parathyroid hormone-related peptide receptorQ03431T67710Not Available
Electrolyte imbalanceOsteocalcinP02818Not AvailableNot Available
Myocardial disordersCaspase-3P70677Not AvailableNot Available
Renal tubular disorderLysozyme CP61626T10586Not Available
Renal tubular disorderBeta-hexosaminidase subunit alphaP06865Not AvailableNot Available
Skin toxicityPeroxiredoxin-5, mitochondrialP30044T77009Not Available
Skin toxicityGlutathione peroxidase 3P23764Not AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain07.01.05.002--
Acne23.02.01.001--Not Available
Acute myeloid leukaemia16.01.05.001; 01.10.05.001--Not Available
Alanine aminotransferase increased13.03.01.003--
Alopecia23.02.02.001--
Anaemia01.03.02.001--
Asthenia08.01.01.001--Not Available
Back pain15.03.04.005--
Bundle branch block02.03.01.009--Not Available
Cardiac arrest02.03.04.001--
Cardiomyopathy02.04.01.001--Not Available
Chest pain22.02.08.003; 08.01.08.002; 02.02.02.011--Not Available
Chills15.05.03.016; 08.01.09.001--
Conjunctivitis06.04.01.002; 11.01.06.012--
Constipation07.02.02.001--
Cough22.02.03.001--
Cryptococcosis11.03.04.001--Not Available
Dehydration14.05.05.001--
Depression19.15.01.001--
Dermatitis bullous23.03.01.002--
Dermatitis exfoliative10.01.01.004; 23.03.07.001--
Diarrhoea07.02.01.001--
Dizziness17.02.05.003; 24.06.02.007; 02.01.02.004--
Dry eye06.08.02.001--
Dry skin23.03.03.001--
Dysgeusia17.02.07.003; 07.14.03.001--
Dyspepsia07.01.02.001--
Dysphagia07.01.06.003--
Dyspnoea22.02.01.004; 02.01.03.002--
Ecchymosis24.07.06.002; 23.06.01.001; 01.01.03.001--Not Available
The 1th Page    1 2 3 4    Next   Last    Total 4 Pages