ADReCS

Pharmaceutical Information

Drug Name	Doxorubicin
Drug ID	BADD_D00723
Description	Doxorubicin is a cytotoxic anthracycline antibiotic isolated from cultures of Streptomyces peucetius var. caesius. Doxorubicin binds to nucleic acids, presumably by specific intercalation of the planar anthracycline nucleus with the DNA double helix.
Indications and Usage	Doxorubicin is used to produce regression in disseminated neoplastic conditions like acute lymphoblastic leukemia, acute myeloblastic leukemia, Wilms’ tumor, neuroblastoma, soft tissue and bone sarcomas, breast carcinoma, ovarian carcinoma, transitional cell bladder carcinoma, thyroid carcinoma, gastric carcinoma, Hodgkin’s disease, malignant lymphoma and bronchogenic carcinoma in which the small cell histologic type is the most responsive compared to other cell types. Doxorubicin is also indicated for use as a component of adjuvant therapy in women with evidence of axillary lymph node involvement following resection of primary breast cancer.
Marketing Status	approved; investigational
ATC Code	L01DB01
DrugBank ID	DB00997
KEGG ID	D03899
MeSH ID	D004317
PubChem ID	31703
TTD Drug ID	D07VLY
NDC Product Code	12543-3209; 70121-1218
UNII	80168379AG
Synonyms	Doxorubicin \| Farmiblastina \| Ribodoxo \| Rubex \| Adriamycin \| Adriblastin \| Adriblastine \| Adriblastina \| Adriablastine \| Adriablastin \| Adrimedac \| DOXO-cell \| DOXO cell \| Urokit Doxo-cell \| Urokit Doxo cell \| Doxolem \| Doxorubicin Hexal \| Doxorubicin Hydrochloride \| Hydrochloride, Doxorubicin \| Doxorubicin NC \| Doxorubicina Ferrer Farm \| Doxorubicina Funk \| Doxorubicina Tedec \| Doxorubicine Baxter \| Doxotec \| Myocet \| Onkodox

Chemical Information

Molecular Formula	C27H29NO11
CAS Registry Number	23214-92-8
SMILES	CC1C(C(CC(O1)OC2CC(CC3=C2C(=C4C(=C3O)C(=O)C5=C(C4=O)C(=CC=C5)OC)O)(C(=O)CO)O)N)O
Chemical Structure

ADRs Induced by Drug

*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..

ADR Term	ADReCS ID	ADR Frequency (FAERS)	ADR Severity Grade (FAERS)	ADR Severity Grade (CTCAE)
Angiosarcoma	24.03.06.003; 16.16.03.001	0.000112%		Not Available
Breast cancer recurrent	21.05.01.017; 16.10.01.009	0.000224%		Not Available
Cardiac failure chronic	02.05.01.009	0.000280%		Not Available
Diffuse large B-cell lymphoma recurrent	16.28.02.002; 01.15.02.002	0.000112%		Not Available
Ewing's sarcoma	16.29.03.004; 15.09.03.015	0.000112%		Not Available
Hepatic infarction	24.04.07.007; 09.01.06.017	0.000112%		Not Available
Joint destruction	15.01.08.012	0.000112%		Not Available
Leiomyosarcoma	16.33.07.001; 15.09.03.016	0.000224%		Not Available
Leiomyosarcoma metastatic	16.33.07.002; 15.09.03.017	0.000280%		Not Available
Metastases to bone	16.22.02.005; 15.09.03.006	0.000448%		Not Available
Metastases to lymph nodes	16.22.02.006; 01.09.01.015	0.000224%		Not Available
Neonatal respiratory distress syndrome	18.04.10.003; 22.11.02.010	0.000112%		Not Available
Nephroblastoma	20.01.04.011; 16.08.02.005	0.000168%		Not Available
Palmoplantar keratoderma	23.01.01.007	0.000112%		Not Available
Pneumothorax spontaneous	22.05.02.007	0.000280%		Not Available
Squamous cell carcinoma of the oral cavity	16.13.07.006; 07.21.07.009	0.000672%		Not Available
Squamous cell carcinoma of the tongue	16.13.07.007; 07.21.07.010	0.000168%		Not Available
Uterine leiomyosarcoma	21.07.02.013; 16.33.07.003	0.000112%		Not Available
Ventricular asystole	02.03.04.018	0.000280%		Not Available
Cardiomyopathy acute	02.04.01.008	0.000168%		Not Available
Endothelial dysfunction	24.03.02.028	0.000112%		Not Available
Peripartum cardiomyopathy	18.02.04.004; 02.04.01.011	0.000504%		Not Available
Bone infarction	24.04.05.011; 15.02.04.031	0.000112%		Not Available
Cardiac ventricular thrombosis	02.11.01.008; 24.01.05.006	0.000392%		Not Available
Breast cancer metastatic	21.05.01.016; 16.10.01.008	0.000783%		Not Available
Biliary dilatation	09.02.03.004	0.000224%		Not Available
Right ventricular dysfunction	02.04.02.033	0.000448%
Malignant peritoneal neoplasm	16.13.04.005; 07.21.03.005	0.000112%		Not Available
Peritoneal disorder	07.07.01.010	0.000112%		Not Available
Acute left ventricular failure	02.05.02.005	0.000280%		Not Available

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