Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Doxercalciferol
Drug ID BADD_D00722
Description Doxercalciferol is a synthetic vitamin D2 analog that undergoes metabolic activation in vivo to form 1α,25-dihydroxyvitamin D2 (1α,25-(OH)2D2), a naturally occurring, biologically active form of vitamin D2. Doxercalciferol is indicated for the treatment of secondary hyperparathyroidism in patients with chronic kidney disease on dialysis, as well as for the treatment of secondary hyperparathyroidism in patients with Stage 3 or Stage 4 chronic kidney disease. Doxercalciferol is marketed under the brand name Hectoral by Genzyme Corporation, and is manufactured by Catalent Pharma Solutions, Inc.
Indications and Usage Doxercalciferol is indicated for the treatment of secondary hyperparathyroidism in patients with chronic kidney disease on dialysis, as well as for the treatment of secondary hyperparathyroidism in patients with Stage 3 or Stage 4 chronic kidney disease.
Marketing Status approved
ATC Code H05BX03
DrugBank ID DB06410
KEGG ID D01009
MeSH ID C042533
PubChem ID 5281107
TTD Drug ID D0G5CF
NDC Product Code 11014-0030; 14474-023; 63415-0040; 62135-452; 64980-229; 70121-1393; 11014-0028; 58468-0127; 64980-228; 11014-0029; 71288-802; 55150-358; 62135-451; 64980-230; 54239-010; 43598-850; 58468-0123; 70121-1392; 62332-690; 68180-718; 66499-0011; 23155-540; 0409-1330; 0641-6154; 55150-359; 23155-538; 23155-539; 55150-357; 62135-450; 70121-1408
UNII 3DIZ9LF5Y9
Synonyms 1 alpha-hydroxyergocalciferol | 1alpha-hydroxyvitamin D2 | doxacalciferol | doxercalciferol | 1alpha(OH)2D2 | 1alpha-OHD2 | Hectorol
Chemical Information
Molecular Formula C28H44O2
CAS Registry Number 54573-75-0
SMILES CC(C)C(C)C=CC(C)C1CCC2C1(CCCC2=CC=C3CC(CC(C3=C)O)O)C
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Photophobia17.17.02.006; 06.01.01.004--
Polydipsia14.05.02.001; 05.03.03.002--Not Available
Polyuria20.02.03.002--Not Available
Pruritus23.03.12.0010.337693%
Rash23.03.13.0010.117389%Not Available
Rash erythematous23.03.13.0290.018225%Not Available
Rash pruritic23.03.13.0300.027337%Not Available
Rhinitis22.07.03.006; 11.01.13.004--
Rhinorrhoea22.12.03.021--
Seizure17.12.03.0010.005360%
Sensory disturbance17.02.07.006--Not Available
Sleep disorder19.02.04.001--Not Available
Somnolence19.02.05.003; 17.02.04.006--
Swelling08.01.03.0150.005360%Not Available
Tachycardia02.03.02.0070.005360%Not Available
Throat irritation07.05.05.037; 22.12.03.0290.027337%Not Available
Throat tightness22.12.03.031; 19.01.02.0050.005360%Not Available
Unresponsive to stimuli17.02.05.0310.016081%Not Available
Urinary tract infection20.08.02.001; 11.01.14.004--
Urticaria10.01.06.001; 23.04.02.0010.057354%
Vomiting07.01.07.0030.080939%
Weight decreased13.15.01.005--
Weight increased13.15.01.006--
Mental status changes19.07.01.0010.011792%Not Available
Musculoskeletal discomfort15.03.04.001--Not Available
Growth retardation15.03.05.016; 14.03.02.031; 05.03.02.007--
Disturbance in sexual arousal19.08.04.003--Not Available
Urine output increased13.13.03.002--Not Available
Hot flush24.03.01.005; 21.02.02.001; 08.01.03.0270.041810%
Poisoning12.03.01.004--Not Available
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ADReCS-Target
Drug Name ADR Term Target
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