| Drug Name |
Doxepin hydrochloride |
| Drug ID |
BADD_D00721 |
| Description |
Doxepin is a psychotropic agent with antidepressant and anxiolytic properties.[T559] It is a tertiary amine that can be presented as (E) and (Z) stereoisomers with the (Z) stereoisomer corresponding to [cidoxepin]. Doxepin commonly produces a 5:1 (E):(Z) racemic mixture.[T83]
In a strict sense, doxepin is not a tricyclic antidepressant but it is commonly associated with the class since it shares a lot of properties with members of the drug family including [amitriptyline], [clomipramine], [desipramine], [imipramine], [nortriptyline], [protriptyline] and [trimipramine].[L5977]
Doxepin was developed by Pfizer and FDA approved in 1969 as an antidepressant.[L5971] However, in 2010 it was approved for the treatment of insomnia. The latter indication was presented by Pernix Therapeutics.[L5974] |
| Indications and Usage |
- Indicated for the short-term (up to 8 days) management of moderate pruritus in adult patients with atopic dermatitis or lichen simplex chronicus [L1344]. |
| Marketing Status |
Prescription; Discontinued |
| ATC Code |
D04AX01; N06AA12 |
| DrugBank ID |
DB01142
|
| KEGG ID |
D00814
|
| MeSH ID |
D004316
|
| PubChem ID |
6419921
|
| TTD Drug ID |
D06FES
|
| NDC Product Code |
70518-2401; 0527-4066; 43353-329; 70518-3005; 23155-796; 55700-917; 49884-217; 49884-219; 55801-527; 68071-2314; 60429-969; 42291-247; 0378-8117; 71921-162; 70756-426; 45865-775; 10267-5059; 71921-165; 42847-103; 16714-132; 70518-2468; 69315-159; 50090-3952; 43353-331; 51672-4217; 23155-795; 59746-704; 70756-428; 55700-768; 46708-639; 16714-135; 0378-8130; 0378-5391; 63629-2181; 0378-4250; 23155-797; 59651-175; 27241-168; 59651-174; 0527-4063; 55700-783; 23155-794; 62332-640; 42847-106; 62332-637; 54838-512; 59651-177; 68071-4464; 0378-1049; 45865-103; 69238-1173; 69315-160; 27241-167; 55289-370; 67763-117; 51079-438; 42806-529; 71205-534; 27241-171; 70518-2984; 69238-1171; 46438-0043; 70518-3360; 44183-106; 0378-5390; 0904-7052; 68071-5179; 0904-7053; 51927-0159; 10267-5061; 0378-6410; 55801-529; 70518-2949; 45865-968; 68071-5260; 71921-164; 63629-5033; 46708-637; 71335-2028; 72789-072; 55801-530; 0904-7055; 50090-5286; 49884-221; 10267-5060; 0378-8123; 69238-1166; 70518-3327; 0378-3125; 69238-1172; 63629-2182; 0904-7054; 51079-651; 60429-966; 16714-134; 0527-4065; 68071-2356; 42806-530; 70518-3017; 70518-2274; 60432-651; 60429-970; 71335-1770; 68788-7731; 71554-006; 59651-176; 71335-1704; 71335-1665; 46708-640; 49884-220; 16714-133; 38779-0218; 62332-639; 27241-169; 49884-222; 55801-528; 62332-645; 70518-3374; 60429-967; 70518-3020; 51672-4220; 46708-645; 59746-701; 59746-703; 35356-650; 50090-0278; 59746-702; 46708-638; 63629-2180; 70518-0386; 10267-5063; 0378-5375; 27241-170; 72189-161; 71335-0072; 72640-003; 63629-3221; 70756-425; 72789-220; 70518-2371; 16714-136; 51672-4219; 71921-163; 71335-1450; 70756-427; 0395-8135; 49452-2692; 17337-0513; 62991-3029; 0378-4810; 0378-4811; 42806-533; 67651-0309; 0527-4062; 70518-2519; 69315-161; 51079-436; 67651-0308; 70756-424; 10267-5062; 71335-0642; 62332-638; 0527-4064; 51672-4221; 55700-928; 51552-0982; 59651-173; 51672-4218; 47621-063; 71921-166; 49884-218; 69315-162; 70518-3314; 60429-968; 71205-610; 70518-3310; 69238-1170; 69315-163; 59746-700; 51927-2227; 44183-103; 69315-158; 51079-437; 71335-1941 |
| Synonyms |
Doxepin | Deptran | Desidox | Doneurin | Doxepia | Doxepin beta | Doxepin Hydrochloride | Hydrochloride, Doxepin | Doxepin Hydrochloride, Cis-Trans Isomer Mixture (approximately 1:5) | Doxepin-RPh | Doxepin RPh | Espadox | Mareen | Novo-Doxepin | Novo Doxepin | Prudoxin | Quitaxon | Sinequan | Sinquan | Zonalon | Xepin | Aponal | Apo-Doxepin | Apo Doxepin | ApoDoxepin |
