Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Doxapram
Drug ID BADD_D00716
Description A central respiratory stimulant with a brief duration of action. (From Martindale, The Extra Pharmocopoeia, 30th ed, p1225)
Indications and Usage For use as a temporary measure in hospitalized patients with acute respiratory insufficiency superimposed on chronic obstructive pulmonary disease.
Marketing Status Prescription; Discontinued
ATC Code R07AB01
DrugBank ID DB00561
KEGG ID D07873
MeSH ID D004315
PubChem ID 3156
TTD Drug ID D0M7BT
NDC Product Code Not Available
Synonyms Doxapram | Dopram | Doxapram Hydrochloride | Hydrochloride, Doxapram | Docatone
Chemical Information
Molecular Formula C24H30N2O2
CAS Registry Number 309-29-5
SMILES CCN1CC(C(C1=O)(C2=CC=CC=C2)C3=CC=CC=C3)CCN4CCOCC4
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Agitation19.06.02.001; 17.02.05.012--
Albuminuria20.02.01.001--Not Available
Anxiety19.06.02.002--
Arrhythmia02.03.02.001--Not Available
Blood pressure increased13.14.03.005--Not Available
Body temperature increased13.15.01.001--Not Available
Bronchospasm22.03.01.004; 10.01.03.012--
Chest discomfort08.01.08.019; 02.02.02.009; 22.02.08.001--Not Available
Chest pain22.02.08.003; 08.01.08.002; 02.02.02.011--Not Available
Clonus17.02.05.002--Not Available
Cough22.02.03.001--
Diarrhoea07.02.01.001--
Disorientation17.02.05.015; 19.13.01.002--Not Available
Dizziness24.06.02.007; 17.02.05.003; 02.01.02.004--
Dyskinesia17.01.02.006--
Dyspnoea22.02.01.004; 02.01.03.002--
Feeling hot08.01.09.009--Not Available
Flushing24.03.01.002; 23.06.05.003; 08.01.03.025--
Hallucination19.10.02.002--
Headache17.14.01.001--
Hiccups22.02.04.002; 07.01.06.009--
Hyperhidrosis23.02.03.004; 08.01.03.028--
Hyperkinesia17.01.02.008--Not Available
Hyperreflexia17.02.01.002--Not Available
Hyperventilation19.01.02.004; 22.02.01.006--Not Available
Hypoventilation22.02.01.007--Not Available
Hypoxia22.02.02.003--
Laryngospasm22.04.02.002--
Leukopenia01.02.02.001--Not Available
Muscle contractions involuntary17.05.03.001; 15.05.03.008--Not Available
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