Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Dornase alfa
Drug ID BADD_D00711
Description Dornase alfa is a biosynthetic form of human deoxyribunuclease I (DNase I) enzyme. It is produced in genetically modified Chinese hamster ovary (CHO) cells using recombinant DNA technology. The 260-amino acid sequence of dornase alfa is identical to the endogenous human enzyme. Dornase alfa cleaves extracellular DNA to 5´-phosphodinucleotide and 5´-phosphooligonucleotide end products without affecting intracellular DNA. In individuals with cystic fibrosis, extracellular DNA, which is an extremely viscous anion, is released by degenerating leukocytes that accumulate during inflammatory responses to infections. Enzymatic breakdown of this extracellular DNA appears to reduce sputum viscosity and viscoelasticity.
Indications and Usage Used as adjunct therapy in the treatment of cystic fibrosis.
Marketing Status approved
ATC Code Not Available
DrugBank ID DB00003
KEGG ID D03896
MeSH ID C568813
PubChem ID Not Available
TTD Drug ID D0JE4D
NDC Product Code 50242-099; 50242-100; 69438-0012
UNII 953A26OA1Y
Synonyms dornase alfa | dornase alpha | rhDNase | recombinant human DNase | recombinant human deoxyribonuclease I | Pulmozyme
Chemical Information
Molecular Formula Not Available
CAS Registry Number 143831-71-4
SMILES Not Available
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain07.01.05.002--
Apnoea22.02.01.001--
Asthenia08.01.01.001--Not Available
Bronchiectasis22.03.02.005--Not Available
Bronchitis22.07.01.001; 11.01.09.001--
Cardiac arrest02.03.04.001--
Cardiac failure02.05.01.001--
Cardio-respiratory arrest22.02.06.007; 02.03.04.002--Not Available
Chest pain22.12.02.003; 08.01.08.002; 02.02.02.011--Not Available
Conjunctivitis11.01.06.012; 06.04.01.002--
Cor pulmonale02.05.03.001; 24.08.03.001; 22.06.01.003--Not Available
Cough22.02.03.001--
Cystic fibrosis22.03.01.015; 07.18.03.001; 03.16.01.002--Not Available
Death08.04.01.001--
Diabetes mellitus05.06.01.001; 14.06.01.001--Not Available
Dyspepsia07.01.02.001--
Dysphonia22.12.03.006; 19.19.03.002; 17.02.08.004--
Dyspnoea22.02.01.004; 02.11.05.003--
Gallbladder disorder09.03.02.001--Not Available
Haemoptysis22.02.03.004; 02.11.04.009; 24.07.01.006--Not Available
Hypoxia22.02.02.003--
Influenza22.07.02.001; 11.05.03.001--Not Available
Intestinal obstruction07.13.01.002--Not Available
Laryngitis22.07.03.001; 11.01.13.001--
Liver disorder09.01.08.001--Not Available
Malaise08.01.01.003--
Nasal polyps22.04.03.010; 16.38.01.001--Not Available
Pancreatic disorder07.18.02.001--Not Available
Pharyngitis22.07.03.004; 11.01.13.003; 07.05.07.004--
Pneumonia22.07.01.003; 11.01.09.003--Not Available
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