Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Docetaxel
Drug ID BADD_D00699
Description Docetaxel is a clinically well established anti-mitotic chemotherapy medication used mainly for the treatment of breast, ovarian, and non-small cell lung cancer. Docetaxel reversibly binds to tubulin with high affinity in a 1:1 stoichiometric ratio
Indications and Usage For the treatment of patients with locally advanced or metastatic breast cancer after failure of prior chemotherapy. Also used as a single agent in the treatment of patients with locally advanced or metastatic non-small cell lung cancer after failure of prior platinum-based chemotherapy. It is also used in combination with prednisone, in the treatment of patients with androgen independent (hormone refractory) metastatic prostate cancer. Furthermore, docetaxel has uses in the treatment of gastric adenocarinoma and head and neck cancer.
Marketing Status Prescription; Discontinued
ATC Code L01CD02
DrugBank ID DB01248
KEGG ID D02165
MeSH ID D000077143
PubChem ID 148124
TTD Drug ID D0O5WP
NDC Product Code 0955-1022; 67457-781; 45963-765; 47335-323; 57884-3042; 66758-050; 43598-611; 43598-258; 54893-0008; 0409-5068; 43598-389; 55150-378; 0955-1020; 72485-214; 0409-0368; 70700-176; 68083-401; 70700-174; 65129-1189; 70121-1223; 65129-1298; 0143-9204; 65129-1141; 47335-895; 0143-9205; 55150-379; 57884-3041; 47335-939; 70121-1222; 70700-175; 0409-4235; 17359-9100; 0409-0367; 16729-267; 68083-400; 68554-0075; 43066-001; 0409-0365; 43066-010; 72485-215; 66758-950; 43598-259; 55150-380; 70747-1004; 68083-399; 70121-1221; 45963-734; 0955-1021; 0409-0366; 43066-006; 43598-610; 72485-216; 57884-3043
Synonyms Docetaxel | Docetaxel Trihydrate | Docetaxol | Docetaxel Hydrate | Taxoltere Metro | RP 56976 | RP-56976 | RP56976 | Taxotere | Docetaxel Anhydrous | N-Debenzoyl-N-tert-butoxycarbonyl-10-deacetyltaxol | N Debenzoyl N tert butoxycarbonyl 10 deacetyltaxol | NSC 628503
Chemical Information
Molecular Formula C43H53NO14
CAS Registry Number 114977-28-5
SMILES CC1=C2C(C(=O)C3(C(CC4C(C3C(C(C2(C)C)(CC1OC(=O)C(C(C5=CC=CC=C5)NC(=O)OC(C)(C)C)O) O)OC(=O)C6=CC=CC=C6)(CO4)OC(=O)C)O)C)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Cell deathCaspase-3P42574T57943Not Available
Cell deathApoptosis regulator Bcl-2P10415T31309Not Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Infusion site reaction12.07.05.006; 08.02.05.005--Not Available
Necrotising enterocolitis neonatal18.04.11.002; 07.08.03.011--Not Available
Haemorrhage24.07.01.002--Not Available
Congestive cardiomyopathy02.04.01.0030.000347%Not Available
Cutaneous lupus erythematosus23.03.02.008; 15.06.02.007; 10.04.03.007--Not Available
Cognitive disorder17.03.03.003; 19.21.02.0010.001332%
Toxic skin eruption23.03.05.003; 10.01.01.0080.000208%Not Available
Cancer pain16.32.03.004--Not Available
Cystoid macular oedema12.02.02.005; 06.04.06.0100.001066%Not Available
Lung neoplasm malignant22.08.01.001; 16.19.02.001--Not Available
Nail toxicity23.02.05.016; 12.03.01.045--Not Available
Angiopathy24.03.02.0070.000139%Not Available
Epidermal necrosis23.03.03.035--Not Available
Neutropenic infection11.01.08.024; 01.02.03.009--Not Available
Skin toxicity23.03.03.032; 12.03.01.0200.000278%Not Available
Blood alkaline phosphatase increased13.04.02.004--
Liver function test normal13.03.01.035--Not Available
Hot flush21.02.02.001; 08.01.03.027; 24.03.01.005--
Recall phenomenon23.03.07.005; 12.02.06.001--
Prostate cancer21.04.02.002; 16.25.01.0010.000278%Not Available
Breast disorder21.05.04.004--Not Available
Cardiac disorder02.01.01.003--Not Available
Connective tissue disorder15.06.01.006--Not Available
Embolism24.01.01.009--
Haematotoxicity01.05.01.007; 12.03.01.0250.001066%Not Available
Infestation11.09.01.001; 23.09.05.001--Not Available
Inflammation08.01.05.0070.004263%Not Available
Intra-abdominal haemorrhage24.07.02.035; 07.12.02.0080.000533%
Malnutrition14.03.02.004--Not Available
Mediastinal disorder22.09.03.001--Not Available
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