Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Docetaxel
Drug ID BADD_D00699
Description Docetaxel is a clinically well established anti-mitotic chemotherapy medication used mainly for the treatment of breast, ovarian, and non-small cell lung cancer. Docetaxel reversibly binds to tubulin with high affinity in a 1:1 stoichiometric ratio
Indications and Usage For the treatment of patients with locally advanced or metastatic breast cancer after failure of prior chemotherapy. Also used as a single agent in the treatment of patients with locally advanced or metastatic non-small cell lung cancer after failure of prior platinum-based chemotherapy. It is also used in combination with prednisone, in the treatment of patients with androgen independent (hormone refractory) metastatic prostate cancer. Furthermore, docetaxel has uses in the treatment of gastric adenocarinoma and head and neck cancer.
Marketing Status Prescription; Discontinued
ATC Code L01CD02
DrugBank ID DB01248
KEGG ID D02165
MeSH ID D000077143
PubChem ID 148124
TTD Drug ID D0O5WP
NDC Product Code 0955-1022; 67457-781; 45963-765; 47335-323; 57884-3042; 66758-050; 43598-611; 43598-258; 54893-0008; 0409-5068; 43598-389; 55150-378; 0955-1020; 72485-214; 0409-0368; 70700-176; 68083-401; 70700-174; 65129-1189; 70121-1223; 65129-1298; 0143-9204; 65129-1141; 47335-895; 0143-9205; 55150-379; 57884-3041; 47335-939; 70121-1222; 70700-175; 0409-4235; 17359-9100; 0409-0367; 16729-267; 68083-400; 68554-0075; 43066-001; 0409-0365; 43066-010; 72485-215; 66758-950; 43598-259; 55150-380; 70747-1004; 68083-399; 70121-1221; 45963-734; 0955-1021; 0409-0366; 43066-006; 43598-610; 72485-216; 57884-3043
Synonyms Docetaxel | Docetaxel Trihydrate | Docetaxol | Docetaxel Hydrate | Taxoltere Metro | RP 56976 | RP-56976 | RP56976 | Taxotere | Docetaxel Anhydrous | N-Debenzoyl-N-tert-butoxycarbonyl-10-deacetyltaxol | N Debenzoyl N tert butoxycarbonyl 10 deacetyltaxol | NSC 628503
Chemical Information
Molecular Formula C43H53NO14
CAS Registry Number 114977-28-5
SMILES CC1=C2C(C(=O)C3(C(CC4C(C3C(C(C2(C)C)(CC1OC(=O)C(C(C5=CC=CC=C5)NC(=O)OC(C)(C)C)O) O)OC(=O)C6=CC=CC=C6)(CO4)OC(=O)C)O)C)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Cell deathApoptosis regulator Bcl-2P10415T31309Not Available
Cell deathCaspase-3P42574T57943Not Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Vomiting07.01.07.003--
Weight decreased13.15.01.005--
Weight increased13.15.01.006--
Wheezing22.03.01.0090.000533%
White blood cell count decreased13.01.06.012--
Cardiotoxicity12.03.01.007; 02.01.01.0020.000278%Not Available
Hand and foot syndrome secondary to sickle cell anaemia23.07.04.011; 01.04.02.003--Not Available
Hypoacusis04.02.01.006--
Peripheral swelling08.01.03.053; 02.05.04.015--Not Available
Emotional distress19.04.02.0080.079657%Not Available
Neutropenic sepsis11.01.11.006; 01.02.03.007--Not Available
Onychomadesis23.02.05.0060.000799%
Left ventricular dysfunction02.04.02.011--
Balance disorder17.02.02.007--Not Available
Lung cancer metastatic22.08.01.004; 16.19.02.0030.000139%Not Available
Sputum purulent22.02.03.008; 11.01.09.0090.000533%Not Available
Deep vein thrombosis24.01.02.003--Not Available
Madarosis23.02.02.004; 06.06.04.0100.001332%Not Available
Fluid imbalance14.05.01.003--Not Available
Malignant neoplasm progression16.16.01.0050.000973%Not Available
Generalised erythema23.03.06.0080.000533%Not Available
Acute coronary syndrome24.04.04.011; 02.02.02.015--Not Available
Necrotising colitis07.08.01.013--Not Available
Lymphatic disorder01.09.01.003--Not Available
Foetor hepaticus09.01.05.006; 07.01.06.026--Not Available
Musculoskeletal discomfort15.03.04.001--Not Available
Inappropriate antidiuretic hormone secretion14.05.07.001; 05.03.03.0010.000533%Not Available
Febrile bone marrow aplasia08.05.02.005; 01.03.03.0070.001865%Not Available
Skin swelling23.03.03.0390.000799%Not Available
Dacryostenosis acquired06.06.04.003--Not Available
The 12th Page    First    Pre   12 13 14 15    Next   Last    Total 15 Pages