Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Dobutamine
Drug ID BADD_D00697
Description A beta-1 agonist catecholamine that has cardiac stimulant action without evoking vasoconstriction or tachycardia. It is proposed as a cardiotonic after myocardial infarction or open heart surgery.
Indications and Usage For inotropic support in the short- term treatment of patients with cardiac decompensation due to depressed contractility resulting either from organic heart disease or from cardiac surgical procedures
Marketing Status Prescription; Discontinued
ATC Code C01CA07
DrugBank ID DB00841
KEGG ID D03879
MeSH ID D004280
PubChem ID 36811
TTD Drug ID D0J7RK
NDC Product Code 51662-1330; 0409-2344; 51662-1337
Synonyms Dobutamine | Dobucor | Dobuject | Dobutamin Fresenius | Dobutamin Hexal | Dobutamin Solvay | Dobutamin-ratiopharm | Dobutamin ratiopharm | Dobutamina Inibsa | Dobutamina Rovi | Posiject | Dobutamine Hydrobromide | Hydrobromide, Dobutamine | Dobutamine Hydrochloride | Hydrochloride, Dobutamine | Dobutamine Lactobionate | Lactobionate, Dobutamine | Dobutamine Tartrate | Tartrate, Dobutamine | Dobutamine Tartrate (1:1), (S-(R*,R*))-Isomer | Dobutamine Tartrate (1:1), (R-(R*,R*))-Isomer | Dobutamine, (-)-Isomer | Dobutamine, Phosphate (1:1) Salt (+)-Isomer | Dobutrex | Lilly 81929 | Oxiken | Dobutamine Phosphate (1:1) Salt, (-)-Isomer | Dobutamine (+)-Isomer
Chemical Information
Molecular Formula C18H23NO3
CAS Registry Number 34368-04-2
SMILES CC(CCC1=CC=C(C=C1)O)NCCC2=CC(=C(C=C2)O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Skin necrosis23.03.03.011--Not Available
Speech disorder22.02.05.034; 19.19.02.002; 17.02.08.0030.000371%Not Available
Tachycardia02.03.02.007--Not Available
Thrombocytopenia01.08.01.002--Not Available
Tremor17.01.06.0020.000742%
Ventricular arrhythmia02.03.04.0060.000242%
Ventricular extrasystoles02.03.04.0070.000556%Not Available
Dry gangrene24.04.03.018; 23.06.06.0030.000371%Not Available
Ejection fraction decreased13.14.02.0030.000556%
Haemodynamic instability24.03.02.0060.000371%Not Available
Dysphemia19.19.03.005; 17.02.08.0100.000371%Not Available
Cardiac disorder02.01.01.0030.002032%Not Available
Ischaemia24.04.02.0040.000371%Not Available
Multiple organ dysfunction syndrome08.01.03.0570.000145%
Cardiac stress test abnormal13.14.02.0160.011127%Not Available
Left ventricle outflow tract obstruction02.08.01.009; 24.03.03.035; 03.07.10.0030.000194%Not Available
Stress cardiomyopathy24.04.04.026; 02.04.01.0120.002782%Not Available
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