Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Dipyridamole
Drug ID BADD_D00692
Description A phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells. Dipyridamole also potentiates the antiaggregating action of prostacyclin. (From AMA Drug Evaluations Annual, 1994, p752)
Indications and Usage For as an adjunct to coumarin anticoagulants in the prevention of postoperative thromboembolic complications of cardiac valve replacement and also used in prevention of angina.
Marketing Status Prescription; Discontinued
ATC Code B01AC07
DrugBank ID DB00975
KEGG ID D00302
MeSH ID D004176
PubChem ID 3108
TTD Drug ID D0F9GE
NDC Product Code 62559-236; 64980-133; 0115-1070; 62559-237; 69584-182; 65841-664; 64980-135; 65404-005; 65015-782; 65841-662; 51407-628; 0115-1071; 0527-1461; 51662-1447; 69584-183; 65841-663; 62559-235; 0641-2569; 0527-1463; 51407-626; 68166-003; 0404-9852; 66039-917; 0527-1462; 71205-894; 52584-569; 51927-1571; 51407-627; 70896-2025; 68382-187; 0115-1072; 68382-188; 68382-189; 12660-0084; 69584-181; 17511-122; 64980-134; 71205-896; 71205-895
Synonyms Dipyridamole | Dipyramidole | Apo-Dipyridamole | Apo Dipyridamole | Cerebrovase | Persantine | Persantin | Curantil | Curantyl | Kurantil | Miosen | Novo-Dipiradol | Novo Dipiradol | Antistenocardin | Cléridium
Chemical Information
Molecular Formula C24H40N8O4
CAS Registry Number 58-32-2
SMILES C1CCN(CC1)C2=NC(=NC3=C2N=C(N=C3N4CCCCC4)N(CCO)CCO)N(CCO)CCO
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Thirst14.03.02.007; 08.01.09.021--Not Available
Thrombocytopenia01.08.01.002--Not Available
Tinnitus17.04.07.004; 04.04.01.002--
Transient ischaemic attack17.08.04.001; 24.04.06.005--
Tremor17.01.06.002--
Urticaria23.04.02.001; 10.01.06.001--
Ventricular arrhythmia02.03.04.006--
Ventricular extrasystoles02.03.04.007--Not Available
Ventricular fibrillation02.03.04.008--
Ventricular tachycardia02.03.04.010--
Vertigo17.02.12.002; 04.04.01.003--
Vomiting07.01.07.0030.006711%
Emotional distress19.04.02.008--Not Available
Cardiac death08.04.01.007; 02.03.04.015--Not Available
Post procedural haemorrhage24.07.01.014; 12.02.05.004--
Acute coronary syndrome24.04.04.011; 02.02.02.015--Not Available
Lymphatic disorder01.09.01.003--Not Available
Epigastric discomfort07.01.02.004--Not Available
Musculoskeletal discomfort15.03.04.001--Not Available
Haemorrhagic transformation stroke24.07.04.018; 17.08.01.0360.004474%Not Available
Haemorrhage24.07.01.002--Not Available
Rectal tenesmus15.05.03.011; 07.03.03.001--Not Available
Angiopathy24.03.02.007--Not Available
Hot flush08.01.03.027; 24.03.01.005; 21.02.02.001--
Neurological symptom17.02.05.0100.020132%Not Available
Cardiac disorder02.01.01.003--Not Available
Electrocardiogram change13.14.05.014--Not Available
Electrocardiogram ST-T change13.14.05.015--Not Available
Embolism24.01.01.0090.005252%
Intra-abdominal haemorrhage24.07.02.035; 07.12.02.0080.011185%
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