Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Dimethyl fumarate
Drug ID BADD_D00680
Description Dimethyl fumarate is an anti-inflammatory. It is indicated for multiple sclerosis patients with relapsing forms and is also being investigated for the treatment of psoriasis. The mechanism of action of dimethyl fumarate in multiple sclerosis is not well understood. It is thought to involve dimethyl fumarate degradation to its active metabolite monomethyl fumarate (MMF) then MMF up-regulates the Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) pathway that is activated in response to oxidative stress. Dimethyl fumarate is marketed under the brand name Tecfidera.
Indications and Usage Used in multiple sclerosis patients with relapsing forms.
Marketing Status Prescription
ATC Code L04AX07
DrugBank ID DB08908
KEGG ID D03846
MeSH ID D000069462
PubChem ID 637568
TTD Drug ID D0A7MY
NDC Product Code 64406-007; 68180-776; 63759-0027; 68180-777; 69097-322; 59651-061; 70710-1205; 43598-429; 51407-441; 69238-1318; 82245-0105; 62207-003; 16729-416; 31722-657; 67877-555; 69238-1626; 43598-430; 58159-013; 69539-043; 16729-417; 31722-658; 54864-663; 64406-006; 55111-975; 70710-1416; 69238-1319; 71348-100; 10920-598; 65015-844; 0093-9218; 59285-003; 62512-0074; 62579-301; 50379-0013; 24979-127; 24979-129; 76055-0026; 70771-1532; 71348-101; 69037-0012; 55111-997; 24979-128; 64406-005; 69097-323; 69667-1229; 69539-240; 70710-1204; 0093-9219; 31722-680; 69539-042; 49812-0255; 0378-0396; 66577-043; 69097-552; 68180-778; 70771-1531; 70771-1530; 0378-0399; 51407-442; 50090-5288; 62675-0393; 67877-556; 66039-901; 67877-557; 62756-178; 71348-102
Synonyms Dimethyl Fumarate | Fumarate, Dimethyl | 2-butenedioic acid, (2E)-, dimethyl ester | Dimethylfumarate | BG 00012 | 00012, BG | BG00012 | BG-00012 | Tecfidera | FAG 201 | 201, FAG | FAG201 | FAG-201 | Fumaderm | BG 12 compound | 12 compound, BG | compound, BG 12 | BG12 compound | compound, BG12 | BG-12 compound
Chemical Information
Molecular Formula C6H8O4
CAS Registry Number 624-49-7
SMILES COC(=O)C=CC(=O)OC
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Spinal cord neoplasm17.20.01.009; 16.30.01.0090.001834%Not Available
Placenta accreta18.05.02.0030.001834%Not Available
Spinal cord oedema17.10.01.0190.001834%Not Available
Amniotic fluid volume decreased13.21.01.0050.001834%Not Available
Relapsing-remitting multiple sclerosis17.16.01.0070.014669%Not Available
Secondary progressive multiple sclerosis17.16.01.0080.013753%Not Available
Primary progressive multiple sclerosis17.16.01.0050.000957%Not Available
Herpes zoster oticus23.09.03.014; 17.04.01.004; 11.05.02.031; 04.01.02.0030.000478%Not Available
Eyelid cyst23.07.04.024; 06.04.04.0160.001834%Not Available
Herpes zoster disseminated11.05.02.0280.001834%Not Available
Ligament rupture15.07.02.008; 12.01.07.0140.005501%Not Available
Bone contusion24.07.06.019; 15.02.04.025; 12.01.08.0410.001834%Not Available
Stress cardiomyopathy24.04.04.026; 02.04.01.012--Not Available
Weight bearing difficulty15.03.01.0270.002751%Not Available
Taciturnity19.19.02.006; 17.02.08.0190.001834%Not Available
Apparent death08.01.03.0620.003667%Not Available
Uhthoff's phenomenon17.16.01.009; 06.02.07.0080.005501%Not Available
Quality of life decreased13.18.01.013--Not Available
Pharyngeal abscess22.07.03.027; 11.01.13.0240.002751%Not Available
JC virus test positive13.08.03.0300.002751%Not Available
Gastrointestinal viral infection11.05.04.016; 07.19.02.0110.001834%Not Available
Tongue pruritus07.14.02.0210.001834%Not Available
Mycobacterium tuberculosis complex test positive13.08.05.0040.001834%Not Available
Oestrogen receptor positive breast cancer16.10.01.016; 21.05.01.0250.001834%Not Available
Band sensation17.16.01.0040.003667%Not Available
Neuroendocrine carcinoma metastatic16.24.01.008; 05.08.01.0120.001834%Not Available
Spinal pain17.10.01.020; 15.02.01.008; 08.01.08.0300.007335%Not Available
Enzyme level increased13.04.02.0150.001834%Not Available
Invasive ductal breast carcinoma16.10.01.013; 21.05.01.0210.027505%Not Available
Invasive lobular breast carcinoma21.05.01.022; 16.10.01.0140.002751%Not Available
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