Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Diltiazem
Drug ID BADD_D00674
Description Diltiazem is a benzothiazepine derivative with antihypertensive and vasodilating properties. Approved in 1982 by the FDA, it is a member of the non-dihydropyridine calcium channel blockers drug class. It works through various mechanisms of action, but it primarily works by inhibiting the calcium influx into cardiac and vascular smooth muscle during depolarization.[L10556] Compared to dihydropyridine drugs, such as [nifedipine], that preferentially act on vascular smooth muscle and [verapamil] that directly acts on the heart muscle, diltiazem displays an intermediate specificity to target both the cardiac and vascular smooth muscle.[T28] Being a potent vasodilator, diltiazem is used clinically as an antihypertensive, anti-arrhythmic, and as an anti-anginal agent [L6289] for the management of cardiovascular conditions such as hypertension, chronic stable angina, atrial fibrillation, atrial flutter. Apart from its main FDA-approved indications, diltiazem has also been used for numerous off-label indications, such as anal fissures (in topical formulations), migraine prophylaxis, pulmonary hypertension, and rest-related cramps in the lower extremities.[L6289] Typically available in extended-release oral and intravenous formulations, diltiazem is marketed under various brand names with Cardizem and Tiazac being the most common ones.
Indications and Usage For the treatment of Hypertension
Marketing Status Prescription; Discontinued
ATC Code C05AE03; C08DB01
DrugBank ID DB00343
KEGG ID D07845
MeSH ID D004110
PubChem ID 39186
NDC Product Code Not Available
Synonyms Diltiazem | Cardil | Cardizem | CRD-401 | CRD 401 | CRD401 | Tiazac | Dilacor XR | Dilren | Diltiazem Hydrochloride | Diltiazem Malate | Dilzem | Aldizem | Dilacor
Chemical Information
Molecular Formula C22H26N2O4S
CAS Registry Number 56209-45-1
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Poisoning and toxicityCytochrome P450 2D6P10635T57392Not Available
Sudden cardiac deathPotassium voltage-gated channel subfamily H member 2Q12809T202519927398; 10810773; 10082151; 10408028
Sudden cardiac deathPotassium voltage-gated channel subfamily KQT member 1P51787T495269927398; 10810773; 10082151; 10408028
Sudden cardiac deathSodium channel protein type 5 subunit alphaQ14524T397169927398; 10810773; 10082151; 10408028
Sudden cardiac deathPotassium voltage-gated channel subfamily E member 1P15382Not Available9927398; 10810773; 10082151; 10408028
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.0010.000369%Not Available
Abdominal distension07.01.04.0010.000184%
Abdominal pain07.01.05.002--
Abdominal pain upper07.01.05.003--
Abnormal dreams19.02.03.001; Available
Acute hepatic failure09.01.03.0010.000072%Not Available
Agranulocytosis01.02.03.001--Not Available
Alanine aminotransferase13.03.01.031--Not Available
Alanine aminotransferase increased13.03.01.0030.000184%
Albuminuria20.02.01.001--Not Available
Amblyopia06.02.01.001--Not Available
Anaphylactic shock24.06.02.004; Available
Angina pectoris24.04.04.002;
Angioedema23.04.01.001; Available
Anuria20.01.03.0020.000277%Not Available
Aortic aneurysm rupture24.02.03.0030.000048%Not Available
Arrhythmia02.03.02.0010.000461%Not Available
Arthropathy15.01.01.003--Not Available
Aspartate aminotransferase increased13.03.01.0060.000184%
Asthenia08.01.01.0010.000461%Not Available
Atrial fibrillation02.03.03.0020.000461%
Atrioventricular block02.03.01.0020.000461%Not Available
Atrioventricular block complete02.03.01.0030.000369%
Atrioventricular block first degree02.03.01.0040.000461%
Atrioventricular block second degree02.03.01.005--
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