Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Dihydrocodeine
Drug ID BADD_D00670
Description Dihydrocodeine is an opioid analgesic used as an alternative or adjunct to codeine to treat moderate to severe pain, severe dyspnea, and cough. It is semi-synthetic, and was developed in Germany in 1908 during an international search to find a more effective antitussive agent to help reduce the spread of airborne infectious diseases such as tuburculosis. It was marketed in 1911.
Indications and Usage
Marketing Status Not Available
ATC Code N02AA08
DrugBank ID DB01551
KEGG ID D07831
MeSH ID C014481
PubChem ID 5284543
TTD Drug ID D0T6RC
NDC Product Code Not Available
Synonyms dihydrocodeine | dihydrocodeine, (5alpha,6alpha,14alpha)-isomer | dihydrocodeine, (5alpha,6beta,14alpha)-isomer | paramol 118 | dihydrocodeine, (5alpha,6beta)-isomer | Rikodeine | Tiamon | Tosidrin | Contugesic | DF 118 | DHC Continus | DHC Mundipharma | Dicodin | dihydrocodeine acetate, (5alpha,6alpha)-isomer | dihydrocodeine bitartrate | dihydrocodeine hydrochloride, (5alpha,6alpha)-isomer | dihydrocodeine phosphate (1:1), (5alpha,6alpha)-isomer | dihydrocodeine tartrate (1:1), (5alpha,6alpha)-(R-(R*,R*))-isomer | dihydrocodeine tartrate (1:1), (5alpha,6beta)-(R-(R*,R*))-isomer | Paracodin | Paracodina | dihydrocodeine, thiocyanate salt (5alpha,6alpha)-isomer
Chemical Information
Molecular Formula C18H23NO3
CAS Registry Number 125-28-0
SMILES CN1CCC23C4C1CC5=C2C(=C(C=C5)OC)OC3C(CC4)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain07.01.05.002--
Angioedema23.04.01.001; 10.01.05.009--Not Available
Asthenia08.01.01.001--Not Available
Biliary colic09.02.01.001--Not Available
Confusional state19.13.01.001; 17.02.03.005--
Constipation07.02.02.001--
Dermatitis23.03.04.002--Not Available
Diarrhoea07.02.01.001--
Dizziness02.01.02.004; 24.06.02.007; 17.02.05.003--
Dry mouth07.06.01.002--
Dysphoria19.04.02.004--Not Available
Dyspnoea22.02.01.004; 02.01.03.002--
Ear disorder04.03.01.001--Not Available
Feeling abnormal08.01.09.014--Not Available
Gastrointestinal disorder07.11.01.001--Not Available
Gastrointestinal pain07.01.05.005--
Hallucination19.10.02.002--
Headache17.14.01.001--
Hyperhidrosis23.02.03.004; 08.01.03.028--
Hypotension24.06.03.002--
Ileus paralytic07.02.05.001--Not Available
Immune system disorder10.02.01.001--Not Available
Mood swings19.04.03.001--Not Available
Nausea07.01.07.001--
Nervous system disorder17.02.10.001--Not Available
Paraesthesia17.02.06.005--
Pruritus23.03.12.001--
Rash23.03.13.001--Not Available
Respiratory depression22.02.01.010; 17.02.05.047--Not Available
Seizure17.12.03.001--
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