| Pharmaceutical Information |
| Drug Name |
Diclofenac epolamine |
| Drug ID |
BADD_D00654 |
| Description |
Diclofenac is a phenylacetic acid derivative and non-steroidal anti-inflammatory drug (NSAID).[label] NSAIDs inhibit cyclooxygenase (COX)-1 and-2 which are the enzyme responsible for producing prostaglandins (PGs). PGs contribute to inflammation and pain signalling. Diclofenac, like other NSAIDs, is often used as first line therapy for acute and chronic pain and inflammation from a variety of causes. Diclofenac was the product of rational drug design based on the structures of [phenylbutazone], [mefenamic acid], and [indomethacin].[A180796] The addition of two chlorine groups in the ortho position of the phenyl ring locks the ring in maximal torsion which appears to be related to increased potency. It is often used in combination with [misoprostol] to prevent NSAID-induced gastric ulcers. Diclofenac was first approved by the FDA in July 1988 under the trade name Voltaren, marketed by Novartis (previously Ciba-Geigy).[L7360] |
| Indications and Usage |
For the acute and chronic treatment of signs and symptoms of osteoarthritis and rheumatoid arthritis. |
| Marketing Status |
Prescription |
| ATC Code |
D11AX18; M01AB05; M02AA15; S01BC03 |
| DrugBank ID |
DB00586
|
| KEGG ID |
D07818
|
| MeSH ID |
C064142
|
| PubChem ID |
114753
|
| TTD Drug ID |
Not Available
|
| NDC Product Code |
46438-0628; 63629-4762; 64032-0017; 0093-3727; 71858-0305; 54871-1093; 0093-3225; 55700-886; 71858-0405; 59762-0411; 60793-411; 62512-0046; 55700-801; 60793-132; 55700-807; 70518-3000; 59762-0707 |
| Synonyms |
diclofenac hydroxyethylpyrrolidine | diclofenac 1-(2-hydroxyethyl)pyrrolidinium salt | N-(2-hydroxyethyl)pyrrolidinium (2-((2,6-dichlorophenyl)amino)phenyl)acetate | diclofenac-N-(2-hydroxyethyl) pyrrolidine | DIEP | DHEP | diclofenac-epolamine | Flector |
|
| Chemical Information |
| Molecular Formula |
C20H24Cl2N2O3 |
| CAS Registry Number |
119623-66-4 |
| SMILES |
C1CCN(C1)CCO.C1=CC=C(C(=C1)CC(=O)O)NC2=C(C=CC=C2Cl)Cl |
| Chemical Structure |
|
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| ADR Related Proteins Induced by Drug |
| ADR Term |
Protein Name |
UniProt AC |
TTD Target ID |
PMID |
| Not Available | Not Available | Not Available | Not Available | Not Available |
|
| ADRs Induced by Drug |
|
| ADR Term |
ADReCS ID |
ADR Frequency (FAERS)
|
ADR Severity Grade (FAERS)
|
ADR Severity Grade (CTCAE)
|
| Application site dryness | 23.03.03.024; 12.07.01.011; 08.02.01.011 | - | - | Not Available |
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