Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Diamminedichloroplatinum
Drug ID BADD_D00643
Description Cisplatin, cisplatinum or cis-diamminedichloroplatinum(II) (CDDP) is a platinum-based chemotherapy drug used to treat various types of cancers, including sarcomas, some carcinomas (e.g. small cell lung cancer, and ovarian cancer), lymphomas and germ cell tumors. It was the first member of its class, which now also includes carboplatin and oxaliplatin.
Indications and Usage For the treatment of metastatic testicular tumors, metastatic ovarian tumors and advanced bladder cancer.
Marketing Status Prescription; Discontinued
ATC Code L01XA01
DrugBank ID DB00515
KEGG ID D00275
MeSH ID D002945
PubChem ID 441203
TTD Drug ID D08ZRW
NDC Product Code 43744-068; 50711-0001; 44567-509; 68001-283; 54875-0001; 0703-5748; 68554-0077; 72659-864; 0143-9504; 49812-0009; 0703-5747; 44567-511; 44567-530; 63323-103; 49452-2078; 72969-014; 16729-288; 68083-162; 68083-163; 70860-206; 44567-510; 0143-9505
Synonyms Cisplatin | cis-Diamminedichloroplatinum(II) | Platinum Diamminodichloride | Diamminodichloride, Platinum | cis-Platinum | cis Platinum | Dichlorodiammineplatinum | cis-Diamminedichloroplatinum | cis Diamminedichloroplatinum | cis-Dichlorodiammineplatinum(II) | NSC-119875 | Platino | Platinol | Biocisplatinum | Platidiam
Chemical Information
Molecular Formula Cl2H6N2Pt+2
CAS Registry Number 15663-27-1
SMILES N.N.Cl[Pt+2]Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Acute kidney injuryNuclear receptor coactivator 1Q15788Not AvailableNot Available
Acute kidney injuryPeroxisomal acyl-coenzyme A oxidase 1Q15067Not AvailableNot Available
Acute kidney injuryRetinoic acid receptor RXR-alphaP19793T13726Not Available
ApoptosisCaspase-6P55212T2060010663637; 11992538; 11351255; 12376980
ApoptosisMitogen-activated protein kinase 14Q16539T6586410403393; 8972197; 12181357
ApoptosisCellular tumor antigen p53P04637T157397761100; 11059757; 9811465; 8883415; 15771712; 10072445; 15550400
ApoptosisCyclic AMP-dependent transcription factor ATF-2P16951Not Available10403393; 8972197; 12181357
ApoptosisCaspase-3P42574T5794310663637; 11351255; 12376980
ApoptosisCaspase-8Q14790T1570010663637; 11992538; 11351255; 12376980
ApoptosisEpidermal growth factor receptorP00533T593289060958; 1683484; 1981005; 9127818; 11967601; 9390057; 12503773
ApoptosisTranscription factor JunP05627Not Available10403393; 8972197; 12181357
ApoptosisE3 ubiquitin-protein ligase Mdm2P23804Not Available7761100; 11059757; 9811465; 8883415; 15771712; 10072445; 15550400
Cell deathCellular tumor antigen p53P04637T157397761100; 11059757; 9811465; 8883415; 15771712; 10072445; 15550400
Cell deathMitogen-activated protein kinase 1P28482T58970Not Available
Cell deathMitogen-activated protein kinase 8P45983T40097Not Available
Cell deathMitogen-activated protein kinase 3P27361T23276Not Available
Cell deathPeroxiredoxin-2P32119Not AvailableNot Available
Electrolyte imbalanceParathyroid hormone/parathyroid hormone-related peptide receptorQ03431T677108400511; 1392187; 6853131; 820624; 1169899; 231063; 6691353; 2995735
Electrolyte imbalanceOsteocalcinP02818Not Available8400511; 1392187; 6853131; 820624; 1169899; 231063; 6691353; 2995735
GlycosuriaSodium/potassium-transporting ATPase subunit alpha-1Q9N0Z6Not Available7839366; 8584502; 1561386
HypersensitivityATP-dependent bile acid permeaseP32386Not Available9016341; 8913338; 7917418; 7551732
HypertrophyGlutathione hydrolase 1 proenzymeP19440Not Available8125216; 8457719; 1508841; 7785052; 15856183; 8494733; 8720036; 15223355
HypertrophyGlutathione hydrolase 1 proenzymeP19440Not Available12792879; 15893589; 12123741
Neoplasm related morbiditiesApoptosis regulator Bcl-2P10415T3130914716031; 15364135; 14977831; 14668933
Neoplasm related morbiditiesTumor necrosis factor receptor superfamily member 10BO14763T7006714716031; 15364135; 14977831; 14668933
Nephropathy toxicLanosterol 14-alpha demethylaseQ8K0C4Not Available1857484; 2309243; 2772925; 15946783
Nephropathy toxicCellular tumor antigen p53P10361Not Available25640527
Nephropathy toxicGlutathione S-transferase PP04906Not Available1857484; 2309243; 2772925; 15946783
Nephropathy toxicGlutathione hydrolase 1 proenzymeP19440Not Available8125216; 8457719; 1508841; 7785052; 15856183; 8494733; 8720036; 15223355
Nephropathy toxicGlutathione peroxidase 1P07203T7065410569399; 10912697; 10842591; 9353848
Nephropathy toxicXylosyl- and glucuronyltransferase LARGE2Q6P7A1Not Available1857484; 2309243; 2772925; 15946783
Nephropathy toxicGlutathione peroxidase 1P07203T706541857484; 2309243; 2772925; 15946783
Nephropathy toxicL-lactate dehydrogenase A chainP00338T150538125216; 8457719; 1508841; 7785052; 15856183; 8494733; 8720036; 15223355
Nephropathy toxicGlutathione hydrolase 1 proenzymeP19440Not Available12792879; 15893589; 12123741
Nephropathy toxicBeta-hexosaminidase subunit alphaP06865Not Available8125216; 8457719; 1508841; 7785052; 15856183; 8494733; 8720036; 15223355
Nephropathy toxicInterleukin-6P20607Not Available25640527
OtotoxicityGlutathione peroxidase 1P07203T7065410569399; 10912697; 10842591; 9353848
OtotoxicityGlutathione reductase, mitochondrialP00390T3080310569399; 10912697; 10842591; 9353848
OtotoxicitySuperoxide dismutase [Cu-Zn]P00441T229778223958; 8004387; 9010480; 8181539; 14740147; 9258999; 16079468; 11243577; 9928884
OtotoxicityCatalaseP04040T015978223958; 8004387; 9010480; 8181539; 14740147; 9258999; 16079468; 11243577; 9928884
OtotoxicityGlutathione peroxidase 1P07203T706541857484; 2309243; 2772925; 15946783
OtotoxicitySuperoxide dismutase [Cu-Zn]P00441T2297710569399; 10912697; 10842591; 9353848
OtotoxicityCatalaseP04040T0159710569399; 10912697; 10842591; 9353848
Renal injuryInterleukin-6P20607Not Available25640527
Renal injuryCellular tumor antigen p53P10361Not Available25640527
VomitingSuperoxide dismutase [Cu-Zn]P00441T2297710569399; 10912697; 10842591; 9353848
VomitingCatalaseP04040T0159710569399; 10912697; 10842591; 9353848
Vomiting5-hydroxytryptamine receptor 3AP46098T645918385615; 10392309; 1532032; 2166791; 10480662; 10688616; 1548679
VomitingSuperoxide dismutase [Cu-Zn]P00441T229778223958; 8004387; 9010480; 8181539; 14740147; 9258999; 16079468; 11243577; 9928884
VomitingCatalaseP04040T015978223958; 8004387; 9010480; 8181539; 14740147; 9258999; 16079468; 11243577; 9928884
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Acute leukaemia16.01.02.001; 01.10.02.001--Not Available
Ageusia17.02.07.001; 07.14.03.003--Not Available
Alopecia23.02.02.001--
Amnesia19.20.01.001; 17.03.02.001--
Amylase increased13.05.01.009--
Anaemia01.03.02.001--
Anaphylactic shock10.01.07.002; 24.06.02.004--Not Available
Anaphylactoid reaction24.06.03.007; 10.01.07.003--Not Available
Anxiety19.06.02.002--
Areflexia17.02.01.001--Not Available
Arrhythmia02.03.02.001--Not Available
Aspartate aminotransferase increased13.03.01.006--
Asthenia08.01.01.001--Not Available
Azoospermia21.03.03.001--
Blindness17.17.01.003; 06.02.02.001--Not Available
Blindness cortical17.17.01.017; 06.02.02.004--Not Available
Blood creatinine increased13.13.01.004--
Blood uric acid increased13.02.04.001--Not Available
Body temperature increased13.15.01.001--Not Available
Bradycardia02.03.02.002--Not Available
Cardiac failure congestive02.05.01.002--Not Available
Cellulitis23.09.01.001; 11.02.01.001--Not Available
Cerebral arteritis24.05.01.002; 17.08.02.004--Not Available
Cerebrovascular accident24.03.05.001; 17.08.01.007--
Clonus17.02.05.002--Not Available
Conjunctivitis06.04.01.002; 11.01.06.012--
Coronary artery disease24.04.04.006; 02.02.01.001--Not Available
Deafness04.02.01.001--Not Available
Dehydration14.05.05.001--
Dermatitis23.03.04.002--Not Available
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