Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Dextrose
Drug ID BADD_D00640
Description Glucose is a simple sugar (monosaccharide) generated during phosynthesis involving water, carbon and sunlight in plants. It is produced in humans via hepatic gluconeogenesis and breakdown of polymeric glucose forms (glycogenolysis). It circulates in human circulation as blood glucose and acts as an essential energy source for many organisms through aerobic or anaerobic respiration and fermentation. It is primarily stored as starch in plants and glycogen in animals to be used in various metabolic processes in the cellular level. Its aldohexose stereoisomer, dextrose or D-glucose, is the most commonly occurring isomer of glucose in nature. L-glucose is a synthesized enantiomer that is used as a low-calorie sweetener and laxative. The unspecified form of glucose is commonly supplied as an injection for nutritional supplementation or metabolic disorders where glucose levels are improperly regulated. Glucose is listed on the World Health Organization's List of Essential Medicines.
Indications and Usage Glucose pharmaceutical formulations (oral tablets, injections) are indicated for caloric supply and carbohydrate supplementation in case of nutrient deprivation. It is also used for metabolic disorders such as hypoglycemia.[L787]
Marketing Status Prescription; Discontinued
ATC Code B05CX01; V04CA02; V06DC01
DrugBank ID DB09341
KEGG ID D02325
MeSH ID D005947
PubChem ID 66370
TTD Drug ID D0C1FY
NDC Product Code 0990-7936; 0264-7520; 0990-7937; 0404-9844; 0264-1510; 0264-7510; 52584-902; 0990-7918; 0264-7387; 51662-1214; 51662-1215; 51662-1306; 0404-9846; 0990-7935; 0409-7937; 51662-1380; 0990-8004; 52584-775
Synonyms Glucose | D-Glucose | D Glucose | Dextrose | Glucose, (alpha-D)-Isomer | Anhydrous Dextrose | Dextrose, Anhydrous | Glucose, (DL)-Isomer | Glucose, (L)-Isomer | L-Glucose | L Glucose | Glucose Monohydrate | Monohydrate, Glucose | Glucose, (beta-D)-Isomer
Chemical Information
Molecular Formula C6H14O7
CAS Registry Number 14431-43-7
SMILES C(C1C(C(C(C(O1)O)O)O)O)O.O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
ApoptosisRenin receptorQ9CYN9Not Available26081285
ApoptosisProtein kinase C beta typeP05771T4027625793913
ApoptosisPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoformP42337Not Available26081285
ApoptosisSerine/threonine-protein kinase mTORQ9JLN9Not Available26081285
ApoptosisRAC-alpha serine/threonine-protein kinaseP31750Not Available26081285
Blood and lymphatic system disordersProtein kinase C beta typeP05771T4027625793913
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Body temperature increased13.15.01.001--Not Available
Death08.04.01.001--
Dehydration14.05.05.001--
Diabetic hyperosmolar coma17.02.09.003; 14.07.04.001; 05.07.04.001--Not Available
Extravasation08.01.03.008--Not Available
Fluid overload14.05.06.001; 02.05.04.004--Not Available
Glycosuria20.02.01.005--
Hyperglycaemia14.06.02.002; 05.06.02.002--
Hyperosmolar state14.05.01.005--Not Available
Hypervolaemia14.05.06.003--Not Available
Injection site infection08.02.03.019; 12.07.03.008; 11.01.08.005--Not Available
Pain08.01.08.004--
Phlebitis24.05.03.001; 12.02.01.002--
Pyrexia08.05.02.003--
Vascular pain24.03.02.026--Not Available
Venous thrombosis24.01.01.008--Not Available
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