| Pharmaceutical Information |
| Drug Name |
Dexrazoxane hydrochloride |
| Drug ID |
BADD_D00634 |
| Description |
An antimitotic agent with immunosuppressive properties. Dexrazoxane, the (+)-enantiomorph of razoxane, provides cardioprotection against anthracycline toxicity. It appears to inhibit formation of a toxic iron-anthracycline complex. [PubChem]
The Food and Drug Administration has designated dexrazoxane as an orphan drug for use in the prevention or reduction in the incidence and severity of anthracycline-induced cardiomyopathy. |
| Indications and Usage |
For reducing the incidence and severity of cardiomyopathy associated with doxorubicin administration in women with metastatic breast cancer who have received a cumulative doxorubicin hydrochloride dose of 300 mg/m^2 and would benefit from continued doxorubicin therapy. Also approved for the treatment of extravasation from intravenous anthracyclines. |
| Marketing Status |
Prescription |
| ATC Code |
V03AF02 |
| DrugBank ID |
DB00380
|
| KEGG ID |
D07807
|
| MeSH ID |
D064730
|
| PubChem ID |
6918223
|
| TTD Drug ID |
D07XVN
|
| NDC Product Code |
76310-110; 51991-942 |
| Synonyms |
Dexrazoxane | Razoxane, (S)-Isomer | Cardioxane | Cardioxan | Zinecard | ICRF-187 | ICRF 187 | ICRF187 | NSC-169780 | NSC 169780 | NSC169780 | ADR-529 | ADR 529 | ADR529 | Dexrazoxane Hydrochloride | Hydrochloride, Dexrazoxane | Razoxane, (S)-Isomer, Hydrochloride |
|
| Chemical Information |
| Molecular Formula |
C11H17ClN4O4 |
| CAS Registry Number |
149003-01-0 |
| SMILES |
CC(CN1CC(=O)NC(=O)C1)N2CC(=O)NC(=O)C2.Cl |
| Chemical Structure |
|
|
| ADR Related Proteins Induced by Drug |
| ADR Term |
Protein Name |
UniProt AC |
TTD Target ID |
PMID |
| Not Available | Not Available | Not Available | Not Available | Not Available |
|
| ADRs Induced by Drug |
|
| ADR Term |
ADReCS ID |
ADR Frequency (FAERS)
|
ADR Severity Grade (FAERS)
|
ADR Severity Grade (CTCAE)
|
| Administration site streaking | 12.07.04.012; 08.02.04.012 | - | - | Not Available |
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