Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Desvenlafaxine
Drug ID BADD_D00621
Description Desvenlafaxine (O-desmethylvenlafaxine) the major active metabolite of venlafaxine, is an antidepressant from the serotonin norepinephrine reuptake inhibitor (SNRI) class[Label]. Desvenlafaxine may be used to treat major depressive disorder[Label]. It is formulated as an extended release tablet[Label]. Desvenlafaxine was approved by the FDA in 2008[L6016].
Indications and Usage Desvenlafaxine is indicated for the treatment of major depressive disorder in adults.
Marketing Status Prescription; Discontinued
ATC Code N06AX23
DrugBank ID DB06700
KEGG ID D07793
MeSH ID D000069468
PubChem ID 125017
TTD Drug ID D0O3FG
NDC Product Code 70436-012; 70436-013; 50090-4806; 0054-0401; 46708-152; 70518-3195; 68382-469; 0591-3659; 71335-1815; 0054-0603; 70436-036; 71335-1753; 51407-023; 0591-4060; 50090-4388; 63304-191; 0591-3660; 14501-0068; 46708-153; 60687-607; 70771-1311; 68382-741; 71335-1975; 0054-0400; 51407-022; 63304-192; 63629-7524; 71335-1700; 70771-1312; 69766-025
Synonyms Desvenlafaxine Succinate | Succinate, Desvenlafaxine | O-desmethylvenlafaxine Succinate Monohydrate | Monohydrate, O-desmethylvenlafaxine Succinate | O desmethylvenlafaxine Succinate Monohydrate | Succinate Monohydrate, O-desmethylvenlafaxine | 2-(1-hydroxycyclohexyl)-2-((4-hydroxyphenyl)ethyl)dimethylammonium 3-carboxypropanoate monohydrate | O-desmethylvenlafaxine Succinate | O desmethylvenlafaxine Succinate | Succinate, O-desmethylvenlafaxine | WY 45,233 | 45,233, WY | WY-45,233 | WY45,233 | WY-45233 | WY45233 | WY 45233 | 45233, WY | Pristiq | Desvenlafaxine | O-desmethylvenlafaxine | O desmethylvenlafaxine | 4-(2-(dimethylamino)-1-(1-hydroxycyclohexyl)ethyl)phenol
Chemical Information
Molecular Formula C16H25NO2
CAS Registry Number 93413-62-8
SMILES CN(C)CC(C1=CC=C(C=C1)O)C2(CCCCC2)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Vertigo17.02.12.002; 04.04.01.003--
Vestibular disorder17.02.02.008; 04.04.02.0010.000846%
Viral infection11.05.04.0010.001269%Not Available
Vision blurred17.17.01.010; 06.02.06.0070.005499%
Visual impairment06.02.06.0080.003807%Not Available
Vomiting07.01.07.0030.010998%
Weight decreased13.15.01.005--
Weight increased13.15.01.0060.007191%
Withdrawal syndrome19.07.02.005; 08.06.02.0120.026648%Not Available
Yawning22.02.05.0170.000846%Not Available
Mobility decreased17.02.05.018; 15.03.01.003; 08.01.03.0300.001269%Not Available
Fibromyalgia15.05.02.0020.000846%Not Available
Hypoacusis04.02.01.0060.001269%
Emotional distress19.04.02.008--Not Available
Abasia17.02.05.035; 08.01.02.0070.000846%Not Available
Homicidal ideation19.05.01.0080.001269%Not Available
Muscle tightness15.05.03.0070.001269%Not Available
Balance disorder17.02.02.0070.001692%Not Available
Bradyphrenia19.10.03.002; 17.03.03.0040.001269%Not Available
Dysstasia17.02.02.0120.001269%Not Available
Contusion24.07.06.001; 23.03.11.002; 15.03.01.008; 12.01.06.0010.002538%
Acute coronary syndrome24.04.04.011; 02.02.02.015--Not Available
Pruritus generalised23.03.12.0030.000846%Not Available
Musculoskeletal stiffness15.03.01.0050.001269%Not Available
Protein urine present13.13.02.006--Not Available
Inappropriate antidiuretic hormone secretion14.05.07.001; 05.03.03.0010.000846%Not Available
Depressive symptom19.15.02.0030.000846%Not Available
Affect lability19.04.01.0010.002538%Not Available
Haemorrhage24.07.01.002--Not Available
Body height decreased13.15.01.0290.000846%Not Available
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