Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Desvenlafaxine
Drug ID BADD_D00621
Description Desvenlafaxine (O-desmethylvenlafaxine) the major active metabolite of venlafaxine, is an antidepressant from the serotonin norepinephrine reuptake inhibitor (SNRI) class[Label]. Desvenlafaxine may be used to treat major depressive disorder[Label]. It is formulated as an extended release tablet[Label]. Desvenlafaxine was approved by the FDA in 2008[L6016].
Indications and Usage Desvenlafaxine is indicated for the treatment of major depressive disorder in adults.
Marketing Status Prescription; Discontinued
ATC Code N06AX23
DrugBank ID DB06700
KEGG ID D07793
MeSH ID D000069468
PubChem ID 125017
TTD Drug ID D0O3FG
NDC Product Code 70436-012; 70436-013; 50090-4806; 0054-0401; 46708-152; 70518-3195; 68382-469; 0591-3659; 71335-1815; 0054-0603; 70436-036; 71335-1753; 51407-023; 0591-4060; 50090-4388; 63304-191; 0591-3660; 14501-0068; 46708-153; 60687-607; 70771-1311; 68382-741; 71335-1975; 0054-0400; 51407-022; 63304-192; 63629-7524; 71335-1700; 70771-1312; 69766-025
Synonyms Desvenlafaxine Succinate | Succinate, Desvenlafaxine | O-desmethylvenlafaxine Succinate Monohydrate | Monohydrate, O-desmethylvenlafaxine Succinate | O desmethylvenlafaxine Succinate Monohydrate | Succinate Monohydrate, O-desmethylvenlafaxine | 2-(1-hydroxycyclohexyl)-2-((4-hydroxyphenyl)ethyl)dimethylammonium 3-carboxypropanoate monohydrate | O-desmethylvenlafaxine Succinate | O desmethylvenlafaxine Succinate | Succinate, O-desmethylvenlafaxine | WY 45,233 | 45,233, WY | WY-45,233 | WY45,233 | WY-45233 | WY45233 | WY 45233 | 45233, WY | Pristiq | Desvenlafaxine | O-desmethylvenlafaxine | O desmethylvenlafaxine | 4-(2-(dimethylamino)-1-(1-hydroxycyclohexyl)ethyl)phenol
Chemical Information
Molecular Formula C16H25NO2
CAS Registry Number 93413-62-8
SMILES CN(C)CC(C1=CC=C(C=C1)O)C2(CCCCC2)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Panic attack19.06.04.0010.004230%Not Available
Panic reaction19.06.04.0030.001269%Not Available
Paraesthesia17.02.06.0050.006768%
Paranoia19.05.01.0050.002115%Not Available
Peripheral coldness08.01.09.010; 24.04.03.006--Not Available
Photophobia17.17.02.006; 06.01.01.0040.001692%
Photopsia17.17.01.006; 06.02.06.0040.000846%
Photosensitivity reaction23.03.09.0030.000846%
Pre-existing condition improved08.01.03.0430.001692%Not Available
Productive cough22.02.03.0050.000846%
Proteinuria20.02.01.011--
Pruritus23.03.12.0010.005922%
Psychotic behaviour19.03.01.0030.001269%Not Available
Pulmonary embolism24.01.06.001; 22.06.02.001--Not Available
Pyrexia08.05.02.003--
Rash23.03.13.0010.009729%Not Available
Rectal haemorrhage24.07.02.018; 07.12.03.001--
Renal disorder20.01.02.002--Not Available
Renal failure20.01.03.005--Not Available
Restlessness19.11.02.002; 17.02.05.0210.002961%
Rhabdomyolysis15.05.05.002--
Screaming19.19.03.0070.001269%Not Available
Sedation17.02.04.0050.001269%Not Available
Seizure17.12.03.0010.007191%
Serotonin syndrome17.05.02.004; 15.05.04.016; 12.03.01.0410.003384%Not Available
Sexual dysfunction21.03.02.003; 19.08.05.0020.004230%Not Available
Shock24.06.02.002--Not Available
Sinus headache22.02.05.023; 17.14.01.0020.001269%
Skin disorder23.03.03.007--Not Available
Skin reaction10.01.03.019; 23.03.03.0130.000846%Not Available
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