Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Desloratadine
Drug ID BADD_D00615
Description Desloratadine is a second generation, tricyclic antihistamine that which has a selective and peripheral H1-antagonist action. It is the active descarboethoxy metabolite of loratidine (a second generation histamine). Desloratidine has a long-lasting effect and does not cause drowsiness because it does not readily enter the central nervous system.
Indications and Usage For the relief of symptoms of seasonal allergic rhinitis, perennial (non-seasonal) allergic rhinitis. Desloratidine is also used for the sympomatic treatment of pruritus and urticaria (hives) associated with chronic idiopathic urticaria.
Marketing Status approved; investigational
ATC Code R06AX27
DrugBank ID DB00967
KEGG ID D03693
MeSH ID C121345
PubChem ID 124087
TTD Drug ID D01GBY
NDC Product Code 53104-7613; 55111-360; 52408-0130; 66577-018; 68180-153; 62993-0805; 75895-0099; 78206-188; 65015-698; 69543-107; 71335-1000; 65691-0057; 66039-830; 50090-3975; 78206-119; 53104-7688; 62331-019; 50090-4794; 62250-619; 42291-240; 55111-551; 55111-073
UNII FVF865388R
Synonyms desloratadine | descarboethoxyloratadine | SCH 34117 | SCH-34117 | Clarinex | Neoclarityn | Aerius | descarboethoxyloratadine acetate
Chemical Information
Molecular Formula C19H19ClN2
CAS Registry Number 100643-71-8
SMILES C1CC2=C(C=CC(=C2)Cl)C(=C3CCNCC3)C4=C1C=CC=N4
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Restlessness19.11.02.002; 17.02.05.021--
Rhinorrhoea22.12.03.0210.003800%
Seizure17.12.03.0010.001357%
Sinus bradycardia02.03.03.0090.000678%
Sleep disorder19.02.04.001--Not Available
Sneezing22.12.03.024--
Somnolence17.02.04.006; 19.02.05.0030.007260%
Speech disorder22.12.03.027; 19.19.02.002; 17.02.08.0030.001018%Not Available
Stevens-Johnson syndrome12.03.01.014; 11.07.01.005; 10.01.01.045; 23.03.01.0070.001357%
Subcutaneous emphysema23.07.04.006; 12.02.06.0020.001018%
Suicidal ideation19.12.01.0030.002714%
Suicide attempt19.12.01.0040.001018%
Swelling08.01.03.0150.000678%Not Available
Swollen tongue23.04.01.014; 10.01.05.015; 07.14.02.003--Not Available
Syncope02.11.04.015; 24.06.02.012; 17.02.04.0080.002985%
Tachycardia02.03.02.0070.001696%Not Available
Throat irritation22.12.03.029; 07.05.05.0370.000678%Not Available
Throat tightness22.12.03.031; 19.01.02.0050.001357%Not Available
Tinnitus17.04.07.004; 04.04.01.002--
Upper respiratory tract infection22.07.03.011; 11.01.13.009--
Urinary retention20.02.02.0110.000678%
Urinary tract infection20.08.02.001; 11.01.14.004--
Urticaria23.04.02.001; 10.01.06.0010.003528%
Varicella23.11.05.008; 11.05.02.004--Not Available
Vertigo17.02.12.002; 04.04.01.0030.001357%
Viral infection11.05.04.001--Not Available
Vomiting07.01.07.0030.003053%
Wheezing22.03.01.0090.001018%
Peripheral swelling08.01.03.053; 02.05.04.015--Not Available
Balance disorder08.01.03.081; 17.02.02.0070.000678%Not Available
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