Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Desloratadine
Drug ID BADD_D00615
Description Desloratadine is a second generation, tricyclic antihistamine that which has a selective and peripheral H1-antagonist action. It is the active descarboethoxy metabolite of loratidine (a second generation histamine). Desloratidine has a long-lasting effect and does not cause drowsiness because it does not readily enter the central nervous system.
Indications and Usage For the relief of symptoms of seasonal allergic rhinitis, perennial (non-seasonal) allergic rhinitis. Desloratidine is also used for the sympomatic treatment of pruritus and urticaria (hives) associated with chronic idiopathic urticaria.
Marketing Status Prescription
ATC Code R06AX27
DrugBank ID DB00967
KEGG ID D03693
MeSH ID C121345
PubChem ID 124087
TTD Drug ID D01GBY
NDC Product Code 53104-7613; 55111-073; 75895-0099; 65691-0057; 62993-0805; 62250-619; 51001-0034; 78206-119; 50090-4794; 53104-7688; 55111-551; 68180-153; 65015-698; 62756-481; 66039-830; 42291-240; 50090-3975; 55111-360; 50090-0765; 71335-1000; 62331-019; 66577-018; 69543-107
Synonyms desloratadine | descarboethoxyloratadine | SCH 34117 | SCH-34117 | Clarinex | Neoclarityn | Aerius | descarboethoxyloratadine acetate
Chemical Information
Molecular Formula C19H19ClN2
CAS Registry Number 100643-71-8
SMILES C1CC2=C(C=CC(=C2)Cl)C(=C3CCNCC3)C4=C1C=CC=N4
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.0010.002643%Not Available
Abdominal pain07.01.05.0020.007930%
Abdominal pain upper07.01.05.0030.002643%
Aggression19.05.01.0010.027756%Not Available
Agitation19.06.02.001; 17.02.05.0120.005287%
Anaphylactic reaction24.06.03.006; 10.01.07.001--
Anaphylactic shock24.06.02.004; 10.01.07.002--Not Available
Angioedema23.04.01.001; 10.01.05.0090.007930%Not Available
Arrhythmia02.03.02.0010.003965%Not Available
Asthenia08.01.01.001--Not Available
Blood bilirubin increased13.03.01.008--
Body temperature increased13.15.01.001--Not Available
Bronchitis11.01.09.001; 22.07.01.001--
Cerebrovascular accident24.03.05.001; 17.08.01.0070.005287%
Chest pain22.02.08.003; 08.01.08.002; 02.02.02.0110.006609%Not Available
Choluria20.02.01.0210.002643%Not Available
Chromaturia20.02.01.0020.002643%
Confusional state19.13.01.001; 17.02.03.0050.002643%
Cough22.02.03.0010.007930%
Crepitations08.01.03.0060.003965%Not Available
Delirium19.13.02.0010.003965%
Depressed level of consciousness17.02.04.0020.003965%
Depressed mood19.15.02.0010.003965%Not Available
Depression19.15.01.0010.009252%
Dermatitis23.03.04.002--Not Available
Diarrhoea07.02.01.001--
Dizziness24.06.02.007; 17.02.05.003; 02.01.02.0040.009252%
Drug abuse19.07.02.0100.001034%Not Available
Drug hypersensitivity10.01.01.0010.006609%Not Available
Dry mouth07.06.01.002--
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