Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Desflurane
Drug ID BADD_D00611
Description Desflurane, or I-653, a a volatile anesthetic that is more rapidly cleared and less metabolized than previous inhaled anesthetics such as [methoxyflurane], [sevoflurane], [enflurane], or [isoflurane].[A226390,A39015,A226893]. It was developed in the late 1980s out of a need for a more rapidly acting and rapidly cleared inhaled anesthetic.[A226883,A226888] Desflurane was granted FDA approval on 18 September 1992.[L30285]
Indications and Usage For use as an inhalation agent for induction and/or maintenance of anesthesia for inpatient and outpatient surgery in adults.
Marketing Status Prescription
ATC Code N01AB07
DrugBank ID DB01189
KEGG ID D00546
MeSH ID D000077335
PubChem ID 42113
TTD Drug ID D0H4GN
NDC Product Code 10019-644; 0781-6172; 52584-641; 10019-641; 0404-9961; 57884-0028; 10019-646
Synonyms Desflurane | 1,2,2,2-Tetrafluoroethyl difluoromethyl ether | I 653 | I-653 | I653 | Suprane
Chemical Information
Molecular Formula C3H2F6O
CAS Registry Number 57041-67-5
SMILES C(C(F)(F)F)(OC(F)F)F
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
NeuritisTransient receptor potential cation channel subfamily A member 1Q8BLA8Not Available25517196
NeuritisTransient receptor potential cation channel subfamily V member 1Q704Y3Not Available25517196
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain07.01.05.002--
Agitation19.06.02.001; 17.02.05.0120.000788%
Alanine aminotransferase increased13.03.01.003--
Ammonia increased13.03.01.023--Not Available
Anaphylactic reaction24.06.03.006; 10.01.07.0010.001182%
Anaphylactic shock24.06.02.004; 10.01.07.0020.000788%Not Available
Apnoea22.02.01.001--
Arrhythmia02.03.02.001--Not Available
Aspartate aminotransferase increased13.03.01.006--
Asthenia08.01.01.001--Not Available
Asthma22.03.01.002; 10.01.03.0100.001182%Not Available
Atrial fibrillation02.03.03.002--
Blindness transient17.17.01.004; 06.02.02.0020.000788%Not Available
Blood bilirubin increased13.03.01.008--
Blood creatine phosphokinase increased13.04.01.001--
Blood creatinine increased13.13.01.004--
Blood glucose increased13.02.02.002--Not Available
Blood pressure systolic decreased13.14.03.0070.000788%Not Available
Body temperature increased13.15.01.001--Not Available
Bone disorder15.02.04.004--Not Available
Bradycardia02.03.02.0020.009458%Not Available
Breath holding22.02.01.016; 19.01.01.002--Not Available
Bronchospasm22.03.01.004; 10.01.03.0120.001182%
Carbon dioxide increased13.02.01.011--Not Available
Carboxyhaemoglobin decreased13.17.02.003--Not Available
Cardiac arrest02.03.04.0010.000308%
Choking22.02.05.0010.000788%Not Available
Cholestasis09.01.01.001--Not Available
Coagulopathy01.01.02.001--Not Available
Conjunctivitis11.01.06.012; 06.04.01.002--
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