Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Deferiprone
Drug ID BADD_D00595
Description Deferiprone is an oral iron chelator used as a second line agent in thalassemia syndromes when iron overload from blood transfusions occurs. Thalassemias are a type of hereditary anaemia due a defect in the production of hemoglobin. As a result, erythropoiesis, the production of new red blood cells, is impaired. FDA approved on October 14, 2011.
Indications and Usage Deferiprone is indicated in thalassemia syndromes when first line chelation agents are not adequate to treat transfusional iron overload.
Marketing Status Prescription
ATC Code V03AC02
DrugBank ID DB08826
KEGG ID D07416
MeSH ID D000077543
PubChem ID 2972
TTD Drug ID D0N0OU
NDC Product Code 10122-101; 10122-103; 0054-0576; 52609-0006; 17349-0023; 10122-104; 0054-0711; 10122-100; 51672-7502; 52609-4502; 51672-4196; 52609-0007
Synonyms Deferiprone | 1,2-Dimethyl-3-hydroxy-4-pyridinone | 1,2 Dimethyl 3 hydroxy 4 pyridinone | DMOHPO | 1,2-Dimethyl-3-hydroxypyrid-4-one | 1,2 Dimethyl 3 hydroxypyrid 4 one | 3-Hydroxy-1,2-dimethyl-4-pyridinone | 3 Hydroxy 1,2 dimethyl 4 pyridinone | HDMPP | 1,2-Dimethyl-3-hydroxypyridin-4-one | 1,2 Dimethyl 3 hydroxypyridin 4 one | Ferriprox
Chemical Information
Molecular Formula C7H9NO2
CAS Registry Number 30652-11-0
SMILES CC1=C(C(=O)C=CN1C)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.0010.008747%Not Available
Abdominal pain07.01.05.002--
Abdominal pain upper07.01.05.0030.005831%
Acute respiratory distress syndrome22.01.03.001--
Agranulocytosis01.02.03.0010.099130%Not Available
Alanine aminotransferase increased13.03.01.003--
Anaemia01.03.02.0010.005831%
Anaphylactic shock24.06.02.004; 10.01.07.002--Not Available
Arthralgia15.01.02.0010.011662%
Arthritis15.01.01.0010.011662%
Arthropathy15.01.01.003--Not Available
Aspartate aminotransferase increased13.03.01.006--
Asthenia08.01.01.0010.014578%Not Available
Atrial fibrillation02.03.03.002--
Back pain15.03.04.0050.008747%
Blood bilirubin increased13.03.01.008--
Blood creatine phosphokinase increased13.04.01.001--
Blood zinc abnormal13.11.01.033--Not Available
Body temperature increased13.15.01.001--Not Available
Bruxism19.11.03.001; 07.01.06.008--Not Available
Cardiac arrest02.03.04.0010.001521%
Cardiac failure02.05.01.001--
Cardiac failure congestive02.05.01.0020.008747%Not Available
Cerebellar syndrome17.02.02.002--Not Available
Cerebral haemorrhage17.08.01.003; 24.07.04.001--Not Available
Cerebrovascular accident24.03.05.001; 17.08.01.007--
Chills15.05.03.016; 08.01.09.0010.008747%
Chromaturia20.02.01.002--
Death08.04.01.0010.016733%
Dehydration14.05.05.001--
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