Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Daunorubicin citrate
Drug ID BADD_D00591
Description A very toxic anthracycline aminoglycoside antineoplastic isolated from Streptomyces peucetius and others, used in treatment of leukemia and other neoplasms.
Indications and Usage For remission induction in acute nonlymphocytic leukemia (myelogenous, monocytic, erythroid) of adults and for remission induction in acute lymphocytic leukemia of children and adults. Daunorubicin is indicated in combination with [cytarabine] for the treatment of newly-diagnosed therapy-related acute myeloid leukemia (t-AML) or AML with myelodysplasia-related changes (AML-MRC) in adults and pediatric patients 1 year and older.[L32843]
Marketing Status approved
ATC Code L01DB02
DrugBank ID DB00694
KEGG ID D10787
MeSH ID D003630
PubChem ID 9961878
TTD Drug ID D01XWG
NDC Product Code Not Available
UNII 5L84T2Z6NP
Synonyms Daunorubicin | Daunomycin | Rubomycin | Dauno-Rubidomycine | Dauno Rubidomycine | Rubidomycin | Daunoblastin | Daunoblastine | NSC-82151 | NSC 82151 | NSC82151 | Cerubidine | Daunorubicin Hydrochloride | Hydrochloride, Daunorubicin
Chemical Information
Molecular Formula C33H37NO17
CAS Registry Number 371770-68-2
SMILES CC1C(C(CC(O1)OC2CC(CC3=C2C(=C4C(=C3O)C(=O)C5=C(C4=O)C(=CC=C5)OC)O)(C(=O)C)O)N)O. C(C(=O)O)C(CC(=O)O)(C(=O)O)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Pulmonary hypertension24.08.03.002; 22.06.01.001--
Pyrexia08.05.02.003--
Rhinitis22.07.03.006; 11.01.13.004--
Seborrhoea23.02.07.001--Not Available
Seizure17.12.03.001--
Sinus tachycardia02.03.03.010--
Somnolence19.02.05.003; 17.02.04.006--
Splenomegaly01.09.02.001--Not Available
Sputum increased22.02.03.007--Not Available
Stomatitis07.05.06.005--
Supraventricular tachycardia02.03.03.012--
Syncope02.11.04.015; 24.06.02.012; 17.02.04.008--
Tachycardia02.03.02.007--Not Available
Thinking abnormal17.02.05.023; 19.10.03.001--Not Available
Thirst14.03.02.007; 08.01.09.021--Not Available
Tinnitus17.04.07.004; 04.04.01.002--
Tremor17.01.06.002--
Ventricular extrasystoles02.03.04.007--Not Available
Vomiting07.01.07.003--
Affect lability19.04.01.001--Not Available
Hot flush24.03.01.005; 21.02.02.001; 08.01.03.027--
Decreased appetite14.03.01.005; 08.01.09.028--
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