Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Dasatinib
Drug ID BADD_D00589
Description Dasatinib is an oral dual BCR/ABL and Src family tyrosine kinase inhibitor approved for use in patients with chronic myelogenous leukemia (CML). The main targets of Dasatinib, are BCRABL, SRC, Ephrins and GFR.
Indications and Usage For the treatment of adults with chronic, accelerated, or myeloid or lymphoid blast phase chronic myeloid leukemia with resistance or intolerance to prior therapy. Also indicated for the treatment of adults with Philadelphia chromosome-positive acute lymphoblastic leukemia with resistance or intolerance to prior therapy.
Marketing Status Prescription
ATC Code L01EA02
DrugBank ID DB01254
KEGG ID D03658
MeSH ID D000069439
PubChem ID 3062316
NDC Product Code 63285-862; 63285-867; 0003-0855; 63285-863; 63285-866; 63285-865; 68554-0070; 54893-0015; 54893-0047; 0003-0857; 0003-0852; 0003-0527; 0003-0528; 76302-014; 50193-0524; 46708-891; 14778-1313; 62207-973; 63285-864; 0003-0524; 59651-468; 53104-7725
Synonyms Dasatinib | N-(2-chloro-6-methylphenyl)-2-(6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-carboxamide | Sprycel | (18F)-N-(2-chloro-6-methylphenyl)-2-(6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-carboxamide | BMS 354825 | 354825, BMS | BMS354825 | BMS-354825
Chemical Information
Molecular Formula C22H26ClN7O2S
CAS Registry Number 302962-49-8
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Anal fissure07.03.01.002--
Anal fistula07.11.05.002--
Anaphylactic reaction24.06.03.006;
Anaphylactic shock24.06.02.004; Available
Angina pectoris24.04.04.002;
Angioedema23.04.01.001; Available
Aortic valve incompetence02.07.03.0010.000533%Not Available
Aplasia08.03.04.003; Available
Aplasia pure red cell10.02.01.003; Available
Aplastic anaemia01.03.03.0020.000208%Not Available
Arrhythmia02.03.02.001--Not Available
Arteriosclerosis coronary artery24.04.04.012; Available
Arthropathy15.01.01.003--Not Available
Aspartate aminotransferase13.03.01.032--Not Available
Aspartate aminotransferase increased13.03.01.006--
Asphyxia22.02.02.001; Available
Aspiration pleural cavity13.19.03.0020.004795%Not Available
Asthenia08.01.01.001--Not Available
Asthma22.03.01.002; Available
Atrial fibrillation02.03.03.002--
Atrial flutter02.03.03.003--
Atrial septal defect03.07.02.002; Available
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