Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Dasatinib
Drug ID BADD_D00589
Description Dasatinib is an oral dual BCR/ABL and Src family tyrosine kinase inhibitor approved for use in patients with chronic myelogenous leukemia (CML). The main targets of Dasatinib, are BCRABL, SRC, Ephrins and GFR.
Indications and Usage For the treatment of adults with chronic, accelerated, or myeloid or lymphoid blast phase chronic myeloid leukemia with resistance or intolerance to prior therapy. Also indicated for the treatment of adults with Philadelphia chromosome-positive acute lymphoblastic leukemia with resistance or intolerance to prior therapy.
Marketing Status Prescription
ATC Code L01EA02
DrugBank ID DB01254
KEGG ID D03658
MeSH ID D000069439
PubChem ID 3062316
TTD Drug ID D0E6XR
NDC Product Code 63285-862; 63285-867; 0003-0855; 63285-863; 63285-866; 63285-865; 68554-0070; 54893-0015; 54893-0047; 0003-0857; 0003-0852; 0003-0527; 0003-0528; 76302-014; 50193-0524; 46708-891; 14778-1313; 62207-973; 63285-864; 0003-0524; 59651-468; 53104-7725
Synonyms Dasatinib | N-(2-chloro-6-methylphenyl)-2-(6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-carboxamide | Sprycel | (18F)-N-(2-chloro-6-methylphenyl)-2-(6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-carboxamide | BMS 354825 | 354825, BMS | BMS354825 | BMS-354825
Chemical Information
Molecular Formula C22H26ClN7O2S
CAS Registry Number 302962-49-8
SMILES CC1=C(C(=CC=C1)Cl)NC(=O)C2=CN=C(S2)NC3=CC(=NC(=N3)C)N4CCN(CC4)CCO
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Orbital oedema06.09.05.001--Not Available
Osteoarthritis15.01.04.0010.001332%Not Available
Osteonecrosis24.04.05.004; 15.02.04.007--
Ovarian cancer16.12.04.001; 21.11.01.0030.000278%Not Available
Oxygen saturation decreased13.02.01.004--Not Available
Pain08.01.08.004--
Pain in extremity15.03.04.0100.015718%
Pain in jaw15.02.01.0030.001332%Not Available
Pain of skin23.03.03.0030.000533%
Pallor24.03.04.001; 23.03.03.031; 08.01.03.032--Not Available
Palmar-plantar erythrodysaesthesia syndrome23.07.04.001; 17.02.07.009--
Palpitations02.01.02.0030.009058%
Pancreatitis07.18.01.001--
Pancreatitis acute07.18.01.002--Not Available
Pancytopenia01.03.03.0030.010656%Not Available
Panic attack19.06.04.001--Not Available
Panniculitis23.07.02.002; 10.01.03.024--Not Available
Papilloedema17.07.02.004; 24.03.07.001; 06.09.02.0020.001066%
Paraesthesia17.02.06.005--
Pelvic pain21.10.01.001; 20.02.03.007; 07.01.06.012--
Pericardial effusion02.06.01.0020.018649%
Pericarditis02.06.02.0010.001865%
Pericarditis constrictive02.06.02.0020.000533%Not Available
Periorbital oedema23.04.01.002; 10.01.05.010; 06.08.03.0170.003197%
Peripheral coldness24.04.03.006; 08.01.09.010--Not Available
Peripheral ischaemia24.04.03.0020.000799%
Peripheral vascular disorder24.03.01.0030.000799%Not Available
Petechiae24.07.06.004; 23.06.01.003; 01.01.03.002--Not Available
Pharyngeal oedema23.04.01.016; 22.04.05.003; 10.01.05.016--Not Available
Pharyngitis streptococcal22.07.04.001; 11.02.06.0020.000799%Not Available
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