Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Dasatinib
Drug ID BADD_D00589
Description Dasatinib is an oral dual BCR/ABL and Src family tyrosine kinase inhibitor approved for use in patients with chronic myelogenous leukemia (CML). The main targets of Dasatinib, are BCRABL, SRC, Ephrins and GFR.
Indications and Usage For the treatment of adults with chronic, accelerated, or myeloid or lymphoid blast phase chronic myeloid leukemia with resistance or intolerance to prior therapy. Also indicated for the treatment of adults with Philadelphia chromosome-positive acute lymphoblastic leukemia with resistance or intolerance to prior therapy.
Marketing Status Prescription
ATC Code L01EA02
DrugBank ID DB01254
KEGG ID D03658
MeSH ID D000069439
PubChem ID 3062316
TTD Drug ID D0E6XR
NDC Product Code 63285-862; 63285-867; 0003-0855; 63285-863; 63285-866; 63285-865; 68554-0070; 54893-0015; 54893-0047; 0003-0857; 0003-0852; 0003-0527; 0003-0528; 76302-014; 50193-0524; 46708-891; 14778-1313; 62207-973; 63285-864; 0003-0524; 59651-468; 53104-7725
Synonyms Dasatinib | N-(2-chloro-6-methylphenyl)-2-(6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-carboxamide | Sprycel | (18F)-N-(2-chloro-6-methylphenyl)-2-(6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-carboxamide | BMS 354825 | 354825, BMS | BMS354825 | BMS-354825
Chemical Information
Molecular Formula C22H26ClN7O2S
CAS Registry Number 302962-49-8
SMILES CC1=C(C(=CC=C1)Cl)NC(=O)C2=CN=C(S2)NC3=CC(=NC(=N3)C)N4CCN(CC4)CCO
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Nausea07.01.07.0010.079390%
Neck pain15.03.04.0090.003463%
Neoplasm16.16.02.001--Not Available
Neoplasm malignant16.16.01.0010.001390%Not Available
Nephrolithiasis20.04.01.002--
Nephropathy20.05.03.0010.001066%Not Available
Nephrotic syndrome20.05.01.0020.005595%
Nervous system disorder17.02.10.001--Not Available
Nervousness19.06.02.003--Not Available
Neuralgia17.02.07.0050.001598%
Neuropathy peripheral17.09.03.0030.008525%Not Available
Neurotoxicity17.02.10.002; 12.03.01.0110.001332%Not Available
Neutropenia01.02.03.0040.012521%Not Available
Neutrophil count decreased13.01.06.0100.003730%
Night sweats23.02.03.006; 08.01.03.0310.002664%Not Available
Nightmare19.02.03.003--Not Available
Nipple disorder21.05.04.0060.000533%
Nipple pain21.05.05.0090.000533%Not Available
Non-Hodgkin's lymphoma16.35.01.001; 01.17.01.0010.000139%Not Available
Ocular hyperaemia06.04.05.004--Not Available
Oedema14.05.06.010; 08.01.07.0060.009591%Not Available
Oedema genital21.10.01.011--
Oedema mouth23.04.01.008; 10.01.05.006; 07.05.04.001--Not Available
Oedema peripheral14.05.06.011; 08.01.07.007; 02.05.04.007--
Oesophageal carcinoma16.13.06.001; 07.21.06.0010.000139%Not Available
Oesophagitis07.08.05.0010.000799%
Oligomenorrhoea21.01.02.004; 05.05.01.0110.000533%Not Available
Optic neuritis17.04.05.001; 10.04.10.002; 06.04.08.002--Not Available
Oral mucosal blistering07.05.05.0170.001332%Not Available
Oral pain07.05.03.002--
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