Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Dapsone
Drug ID BADD_D00580
Description A sulfone active against a wide range of bacteria but mainly employed for its actions against mycobacterium leprae. Its mechanism of action is probably similar to that of the sulfonamides which involves inhibition of folic acid synthesis in susceptible organisms. It is also used with pyrimethamine in the treatment of malaria. (From Martindale, The Extra Pharmacopoeia, 30th ed, p157-8)
Indications and Usage For the treatment and management of leprosy and dermatitis herpetiformis.
Marketing Status approved; investigational
ATC Code D10AX05; J04BA02
DrugBank ID DB00250
KEGG ID D00592
MeSH ID D003622
PubChem ID 2955
TTD Drug ID D0MA9N
NDC Product Code 0023-5206; 29967-0007; 16110-526; 49938-102; 51672-4197; 68308-342; 51927-0085; 53596-014; 13668-605; 70954-135; 0713-0886; 16714-956; 51552-1042; 29033-036; 49938-101; 60429-495; 0378-4830; 14474-038; 50218-008; 51927-0083; 73309-094; 51672-1387; 71052-100; 72375-0006; 16110-367; 29033-037; 43353-222; 51672-1388; 60429-496; 60758-670; 70954-136; 10695-047; 51927-0084; 51672-4198; 46438-0645; 49452-2439; 65571-0021; 76072-1018; 64980-566; 14474-026; 45562-1120; 51927-4368; 58159-033; 43353-223; 0023-3670
UNII 8W5C518302
Synonyms Dapsone | DADPS | Sulfonyldianiline | Diaminodiphenylsulfone | Diaphenylsulfone | 4,4'-Diaminophenyl Sulfone | 4,4' Diaminophenyl Sulfone | Sulfone, 4,4'-Diaminophenyl | Sulfona | Dapson-Fatol | Disulone | Avlosulfone | Dapsoderm-X
Chemical Information
Molecular Formula C12H12N2O2S
CAS Registry Number 80-08-0
SMILES C1=CC(=CC=C1N)S(=O)(=O)C2=CC=C(C=C2)N
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain07.01.05.0020.001723%
Acne23.02.01.0010.007480%Not Available
Acute hepatic failure09.01.03.0010.001100%Not Available
Acute respiratory failure22.02.06.001; 14.01.04.0040.000917%Not Available
Agitation19.06.02.001; 17.02.05.0120.000990%
Agranulocytosis01.02.03.0010.002017%Not Available
Albuminuria20.02.01.001--Not Available
Anaemia01.03.02.0010.003263%
Anoxia22.02.02.009--Not Available
Anuria20.01.03.0020.000367%Not Available
Application site erythema23.03.06.005; 12.07.01.001; 08.02.01.0010.003300%Not Available
Application site irritation08.02.01.003; 12.07.01.0030.001247%Not Available
Application site pain08.02.01.004; 12.07.01.0040.004363%Not Available
Application site pruritus23.03.12.004; 12.07.01.005; 08.02.01.0050.001247%Not Available
Application site reaction12.07.01.006; 08.02.01.006--Not Available
Ascites07.07.01.001; 02.05.04.002; 09.01.05.0030.000733%
Asthenia08.01.01.001--Not Available
Atelectasis22.01.02.0010.000367%
Blister23.03.01.001; 12.01.06.0020.001540%Not Available
Body temperature increased13.15.01.001--Not Available
Bradycardia02.03.02.0020.000367%Not Available
Burning sensation17.02.06.001; 08.01.09.0290.005170%Not Available
Cardiac arrest02.03.04.0010.000550%
Cardiac failure congestive02.05.01.0020.000367%Not Available
Cerebral infarction17.08.01.004; 24.04.06.0020.000367%Not Available
Chest discomfort22.12.02.002; 08.01.08.019; 02.02.02.0090.000367%Not Available
Chills15.05.03.016; 08.01.09.0010.000733%
Cholestasis09.01.01.0010.000550%Not Available
Coagulopathy01.01.02.0010.000367%Not Available
Coma17.02.09.0010.000367%Not Available
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ADReCS-Target
Drug Name ADR Term Target
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