Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Dapsone
Drug ID BADD_D00580
Description A sulfone active against a wide range of bacteria but mainly employed for its actions against mycobacterium leprae. Its mechanism of action is probably similar to that of the sulfonamides which involves inhibition of folic acid synthesis in susceptible organisms. It is also used with pyrimethamine in the treatment of malaria. (From Martindale, The Extra Pharmacopoeia, 30th ed, p157-8)
Indications and Usage For the treatment and management of leprosy and dermatitis herpetiformis.
Marketing Status Prescription
ATC Code D10AX05; J04BA02
DrugBank ID DB00250
KEGG ID D00592
MeSH ID D003622
PubChem ID 2955
TTD Drug ID D0MA9N
NDC Product Code 51927-0084; 70954-135; 49938-102; 65571-0021; 51552-1042; 46438-0645; 49938-101; 49452-2439; 43353-222; 16110-367; 76072-1018; 51927-4368; 53596-014; 70954-136; 58159-033; 51927-0083; 60758-670; 60429-496; 60429-495; 0904-7018; 43353-223; 14474-026; 16714-956; 71052-100; 50218-008; 51672-4197; 29967-0007; 51672-4198; 14474-038; 0023-3670; 0023-5206; 68308-342; 10695-047; 51672-1388; 45562-1120; 51927-0085; 73309-094; 13668-605; 51672-1387; 29033-036; 29033-037; 16110-526; 51672-5307; 0904-7019; 72375-0006
Synonyms Dapsone | DADPS | Sulfonyldianiline | Diaminodiphenylsulfone | Diaphenylsulfone | 4,4'-Diaminophenyl Sulfone | 4,4' Diaminophenyl Sulfone | Sulfone, 4,4'-Diaminophenyl | Sulfona | Dapson-Fatol | Disulone | Avlosulfone | Dapsoderm-X
Chemical Information
Molecular Formula C12H12N2O2S
CAS Registry Number 80-08-0
SMILES C1=CC(=CC=C1N)S(=O)(=O)C2=CC=C(C=C2)N
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
AgranulocytosisMyeloperoxidaseP05164T234717902244; 1664258; 8385460; 2856515; 1650217; 9022075; 1324677; 12060654; 11440179; 9243259; 16214851
HypersensitivityN-alpha-acetyltransferase 20P61599Not AvailableNot Available
Lupus erythematosus (incl subtypes)MyeloperoxidaseP05164T234717902244; 1664258; 8385460; 2856515; 1650217; 9022075; 1324677; 12060654; 11440179; 9243259; 16214851
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain07.01.05.0020.004008%
Acne23.02.01.0010.008017%Not Available
Acute hepatic failure09.01.03.0010.001046%Not Available
Agitation19.06.02.001; 17.02.05.0120.001603%
Agranulocytosis01.02.03.0010.006414%Not Available
Albuminuria20.02.01.001--Not Available
Alveolitis allergic22.01.01.002; 10.01.03.0080.003207%Not Available
Anaemia01.03.02.0010.008017%
Angioedema23.04.01.001; 10.01.05.0090.001603%Not Available
Anoxia22.02.02.009--Not Available
Application site erythema23.03.06.005; 12.07.01.001; 08.02.01.001--Not Available
Application site pain12.07.01.004; 08.02.01.004--Not Available
Application site pruritus08.02.01.005; 23.03.12.004; 12.07.01.005--Not Available
Application site reaction12.07.01.006; 08.02.01.006--Not Available
Asthenia08.01.01.001--Not Available
Back pain15.03.04.005--
Blister23.03.01.001; 12.01.06.0020.003207%Not Available
Blood bilirubin increased13.03.01.0080.001603%
Body temperature increased13.15.01.001--Not Available
Burning sensation17.02.06.001; 08.01.09.0290.005612%Not Available
Cardiac failure congestive02.05.01.002--Not Available
Chest discomfort22.02.08.001; 08.01.08.019; 02.02.02.0090.001603%Not Available
Chest pain22.02.08.003; 08.01.08.002; 02.02.02.011--Not Available
Cholestasis09.01.01.0010.000627%Not Available
Coma17.02.09.0010.000418%Not Available
Cough22.02.03.0010.004810%
Cyanosis24.03.01.007; 22.02.02.007; 02.01.02.0020.003207%
Dermatitis23.03.04.0020.001603%Not Available
Dermatitis exfoliative23.03.07.001; 10.01.01.0040.001603%
Diabetes mellitus14.06.01.001; 05.06.01.0010.000418%Not Available
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