Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Dapagliflozin
Drug ID BADD_D00578
Description Dapagliflozin is a sodium-glucose cotransporter 2 inhibitor indicated for managing diabetes mellitus type 2.[A6757] When combined with diet and exercise in adults, dapagliflozin helps to improve glycemic control by inhibiting glucose resorption in the proximal tubule of the nephron and causing glycosuria.[A6757] Dapagliflozin was approved by the FDA on Jan 08, 2014.[L6034]
Indications and Usage Dapagliflozin is indicated for adjunct management of glycemic control in patients with type 2 diabetes mellitus, in combination with diet and exercise.
Marketing Status Prescription
ATC Code A10BK01
DrugBank ID DB06292
KEGG ID D08897
MeSH ID C529054
PubChem ID 9887712
TTD Drug ID D01TNW
NDC Product Code 17228-6205; 50090-3482; 14501-0028; 55154-6932; 59285-012; 66529-0003; 54921-621; 55111-987; 69037-0027; 65727-073; 12783-1428; 50090-3481; 0310-6205; 17228-6210; 12783-1427; 54921-620; 55154-6933; 46708-897; 66064-1029; 50193-1427; 59651-135; 0310-6210; 66039-933
Synonyms dapagliflozin | (2S,3R,4R,5S,6R)-2-(4-chloro-3-(4-ethoxybenzyl)phenyl)-6- (hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol | Farxiga | Forxiga | 2-(3-(4-ethoxybenzyl)-4-chlorophenyl)-6-hydroxymethyltetrahydro-2H-pyran-3,4,5-triol | BMS 512148 | BMS512148 | BMS-512148
Chemical Information
Molecular Formula C21H25ClO6
CAS Registry Number 461432-26-8
SMILES CCOC1=CC=C(C=C1)CC2=C(C=CC(=C2)C3C(C(C(C(O3)CO)O)O)O)Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Microalbuminuria20.02.01.026; 14.07.02.002; 05.07.02.0020.001206%Not Available
Micturition urgency20.02.02.0060.001809%
Multiple fractures15.08.02.005; 12.04.02.009--Not Available
Muscle spasms15.05.03.0040.009044%
Muscular weakness17.05.03.005; 15.05.06.001--
Musculoskeletal pain15.03.04.007--
Myalgia15.05.02.0010.006029%
Myocardial infarction24.04.04.009; 02.02.02.007--
Nail discolouration23.02.05.0010.001206%
Nasopharyngitis22.07.03.002; 11.01.13.002--Not Available
Nausea07.01.07.001--
Necrotising fasciitis15.03.03.004; 11.01.17.0020.013264%Not Available
Neoplasm16.16.02.001--Not Available
Neoplasm malignant16.16.01.001--Not Available
Neoplasm prostate16.25.02.001; 21.04.02.003--Not Available
Nephritis20.05.02.0010.009044%Not Available
Nephrolithiasis20.04.01.0020.005426%
Nervousness19.06.02.0030.001809%Not Available
Nocturia20.02.03.0010.001809%Not Available
Oedema14.05.06.010; 08.01.07.006--Not Available
Oedema peripheral02.05.04.007; 14.05.06.011; 08.01.07.007--
Oral candidiasis11.03.03.004; 07.05.07.0010.001206%Not Available
Orthostatic hypotension24.06.03.004; 17.05.01.0200.001206%Not Available
Pain08.01.08.004--
Pain in extremity15.03.04.010--
Palpitations02.01.02.0030.004220%
Pancreatic carcinoma16.13.10.001; 07.21.09.0020.000472%Not Available
Pancreatic disorder07.18.02.0010.001206%Not Available
Pancreatitis07.18.01.0010.008441%
Pancreatitis acute07.18.01.0020.002412%Not Available
The 5th Page    First    Pre   5 6 7 8 9    Next   Last    Total 9 Pages